1,6-二磷酸果糖三钠盐缓解小鼠体力疲劳作用研究  

Study on the Effect of D-Fructose 1,6-Bisphosphate Trisodium Salt on Alleviating Physical Fatigue in Mice

作　　者：周赟 王言之 李世芬[1,3] 环飞 张静姝[1,3] 王玉邦 Zhou Yun;Wang Yanzhi;Li Shifen;Huan Fei;Zhang Jingshu;Wang Yubang(School of Public Health,Nanjing Medical University,Nanjing 211166,China;First Clinical Medical College,Nanjing Medical University,Nanjing 211166,China;Safety Assessment and Research Center for Drug,Pesticide and Veterinary Drug of Jiangsu Province,Nanjing 211166,China)

机构地区：[1]南京医科大学公共卫生学院,江苏南京211166 [2]南京医科大学第一临床医学院,江苏南京211166 [3]江苏省医药农药兽药安全性评价与研究中心,江苏南京211166

出　　处：《山东化工》2021年第15期55-57,共3页Shandong Chemical Industry

基　　金：江苏省高校优势学科建设工程资助项目(苏政办发[2018]87号)。

摘　　要：目的:研究1,6-二磷酸果糖三钠盐缓解小鼠体力疲劳的功效。方法:以1,6-二磷酸果糖三钠盐为受试物,分83,167,500 mg/kg·bw/d三个剂量经口给予小鼠一个月,测小鼠的负重游泳时间、血浆尿素水平、肝糖原储备量及血乳酸值。结果:500 mg/kg·bw/d组小鼠负重游泳时间长于0 mg/kg·bw/d组;500 mg/kg·bw/d组小鼠血浆尿素水平低于0 mg/kg·bw/d组;167,500 mg/kg·bw/d组小鼠肝糖原储备量高于0 mg/kg·bw/d组,差异均有统计学意义(P<0.05)。结论:1,6-二磷酸果糖三钠盐具有抗疲劳的功效。Objective:To study the effect of D-fructose 1,6-bisphosphate trisodium salt on alleviating physical fatigue in mice.Methods:Using D-fructose 1,6-bisphosphate trisodium salt as the test substance,three doses of 83,167,500 mg/kg·bw/d were administered orally to mice for one month,then measure the loaded-swimming time,plasma urea level,hepatic glycogen reserve and serum lactate acid value of mice.Results:The loaded-swimming time of the mice in the 500 mg/kg·bw/d group were longer than those in the 0 mg/kg·bw/d group;the plasma urea level of the mice in the 500 mg/kg·bw/d group were lower than those in the 0 mg/kg·bw/d group;the hepatic glycogen reserve of the mice in the 167,500 mg/kg·bw/d groups were higher than those in the 0 mg/kg·bw/d group.The differences were statistically significant(P<0.05).Conclusion:D-fructose 1,6-bisphosphate trisodium salt has the effect of alleviating physical fatigue.

关 键 词：1 6-二磷酸果糖三钠盐 缓解体力疲劳 负重游泳时间 血浆尿素 血乳酸 肝糖原 

分 类 号：R977.9[医药卫生—药品]