伴黏膜受累的成人线状IgA大疱性皮病1例并文献回顾  

Adult Linear IgA Bullous Dermatosis with Mucosal Involvement in one Case and LiteratureReview

作　　者：王金容 张佩莲 黄虹[1] 杨瑾[1] 伍迪[1] 欧阳晓勇[1] 叶建州[1] WANG Jinrong;ZHANG Peilian;HUANG Hong;YANG Jin;WU Di;OUYANG Xiaoyong;YE Jianzhou(Yunnan Provincial Hospital of Traditional Chinese Medicine,Kunming 650021,China)

机构地区：[1]云南省中医医院·云南省中医皮肤病专科医院,云南昆明650021

出　　处：《中国皮肤性病学杂志》2021年第9期1017-1020,共4页The Chinese Journal of Dermatovenereology

基　　金：云南中医药大学第一附属医院中医药防治皮肤病省创新团队(2019HC001)。

摘　　要：患者女,35岁,躯干、四肢红斑、瘙痒半月,加重伴水疱3 d。皮损组织病理示:表皮下水疱,疱液见中性粒细胞,真皮中浅层血管内及周围见中性粒细胞浸润;直接免疫荧光见IgA、IgG基底膜带线状沉积;根据临床表现、组织病理学、免疫荧光诊断为成人线状IgA大疱性皮病。线状IgA大疱性皮病为少见的自身免疫性表皮下大疱病,成人临床表现多样化,易出现误诊。A 35-year-old women presented with erythema and pruritus on her trunk and extremities for half a month,which was aggravated and with blistering for three days.Histopathology of the skin lesion showed subepidermal bulla,neutrophils in the blister fluid,and neutrophil infiltration in and around the superficial blood vessels in the dermis.Direct immunofluorescence demonstrated linear deposition of immunoglobulin A and G at the dermal-epidermal junction.Based on clinical,histopathological,and immunofluorescence findings,the diagnosis was Linear IgA bullous dermatosis.It is a rare autoimmune subepidermal bullous disease,and has diverse clinical manifestations,which is therefore more likely to be misdiagnosed.

关 键 词：IgA大疱性皮病 线状 成人 

分 类 号：R758.66[医药卫生—皮肤病学与性病学]