沙眼衣原体包涵体膜蛋白功能研究进展  

Advances in Functions of Chlamydia Trachomatis Inclusion Membrane Proteins

作　　者：高哲 张荣荣 贾天军[1] GAO Zhe;ZHANG Rongrong;JIA Tianjun(Key Laboratory of Clinical Laboratory Diagnosis,Hebei North University,Zhangjiakou 075000,China)

机构地区：[1]河北北方学院临床检验诊断学重点实验室,河北张家口075000

出　　处：《中国皮肤性病学杂志》2021年第9期1059-1063,共5页The Chinese Journal of Dermatovenereology

基　　金：河北省自然科学基金资助项目(C2020405014)。

摘　　要：沙眼衣原体(Chlamydia trachomatis,Ct)是专性寄生于真核细胞的病原体,侵入宿主细胞后可形成包涵体并分泌大量效应蛋白。其中被转运至包涵体膜且具有特异性结构的蛋白称为包涵体膜蛋白(inclusion membrane protein, Inc蛋白)。Inc蛋白可调节宿主细胞的囊泡运输、非囊泡运输、细胞骨架以及控制子代释放等,是Ct生长至关重要的效应蛋白。本文就Ct Inc蛋白功能最新研究进展进行综述。Chlamydia trachomatis(Ct)is an obligate intracellular pathogen that invades host cells to form inclusion and secretes a diverse array of effector proteins.The proteins which are transported to the inclusion membrane and have specific structures are called inclusion membrane proteins(Incs).Incs are essential for the chlamydial growth,which can regulate the host cell vesicular and non-vesicular transport,cell cytoskeleton and control the release of progeny.This paper reviews recent advances of Incs functions.

关 键 词：沙眼衣原体 包涵体膜蛋白 功能 

分 类 号：R374.1[医药卫生—病原生物学]