系统评价口炎清颗粒治疗慢性咽炎的效果与安全性  

Efficacy and Safety Assessment of Kouyanqing Granule for Chronic Pharyngitis

作　　者：余亚信[1] 陈秋旻 林宝华[1] 王丽英[2] YU Yaxin;CHEN Qiumin;LIN Baohua;WANG Liying(Department of Traditional Chinese Medicine,Xinglin District,The First Affiliated Hospital of Xiamen University,Xiamen Fujian 361022,China;Department of Endocrinology and Diabetes,The First Affiliated Hospital of Xiamen University,Xiamen Fujian 361003,China)

机构地区：[1]厦门大学附属第一医院杏林分院中医科,福建厦门361022 [2]厦门大学附属第一医院内分泌糖尿病科,福建厦门361003

出　　处：《中国卫生标准管理》2021年第15期114-117,共4页China Health Standard Management

摘　　要：目的运用循证医学方法,对口炎清颗粒联合西药治疗慢性咽炎的随机对照试验进行系统评价。方法全面收集1994年1月—2020年1月期间发表的主要以口炎清颗粒联合西药与单纯西药治疗慢性咽炎的随机对照试验文献,分别对各纳入研究进行质量评价;采用Meta分析对多个研究结果进行总体效应评价。结果共有6篇文献符合此次纳入标准。Meta统计荟萃分析结果表明,联合用药组治疗慢性咽炎的临床效果明显优于纯西药组,差异有统计学意义[OR 6.09,95%CI(3.35,11.06),P<0.05];两个用药组的不良反应发生率差异无统计学意义[OR 0.85,95%CI(0.40,1.81),P=0.67]。结论联合用药对慢性咽炎的疗效显著优于单纯西药,且不增加不良反应。但此次系统评价所纳入的研究质量不高,其所得出结论的证据力度难免受到一定程度影响。建议临床医生今后可继续开展更多更高质量的关于联合用药治疗慢性咽炎的效果与安全性的临床试验。Objective To evaluate the randomized control trials on treating patients with chronic pharyngitis by Kouyanqing granule combine with western medicine adopting the principle of evidence-based medicine.Methods Pertinent literatures on randomized controlled trials of kouyanqing granule combined with western medicine or western medicine monotherapy in the treatment of chronic pharyngitis were retrieved roundly during January 1994 to January 2020,and articles’quality were evaluated.Meta-analysis was applied on the total effect of multiple outcomes reported.Results Six studies met the inclusion criteria.Meta-analysis showed that Kouyanqing granule combine with western medicine was more effective compared with western medicine monotherapy[OR 6.09,95%CI(3.35,11.06),P<0.05].There was no difference in the incidence of adverse reactions between the two groups[OR 0.85,95%CI(0.40,1.81),P=0.67].Conclusion Kouyanqing granule combined with western medicine was superior to western medicine monotherapy for patients with chronic pharyngitis without increasing adverse reactions.Due to the poor quality of original articles included in this systematic review,the evidence obtained is not definite in some extent.Our results suggest that clinicians should continue to conduct more high-quality clinical studies on the efficacy and safety of combination therapy for chronic pharyngitis in the future to provide more reliable evidence.

关 键 词：系统评价 口炎清 颗粒 慢性咽炎 随机对照 META分析 

分 类 号：R766[医药卫生—耳鼻咽喉科]