GDF-15水平与2型糖尿病肾病分期相关性Meta分析  

Relationship between GDF-15 level and staging of diabetic nephropathy:a meta-analysis

作　　者：周佳奇 梁栋 周琪 张慧[2] 张清潭[1] ZHOU Jiaqi;LIANG Dong;ZHOU Qi;ZHANG Hui;ZHANG Qingtan(Department of Geriatrics,Binzhou Medical University Hospital,Binzhou 256600,China)

机构地区：[1]滨州医学院附属医院老年医学科,256600 [2]滨州医学院附属医院肾内科,256600

出　　处：《浙江医学》2021年第16期1785-1789,共5页Zhejiang Medical Journal

摘　　要：目的探讨生长分化因子-15(GDF-15)水平与糖尿病肾病(DN)不同分期的关系。方法在CNKI、PubMed、Cochrane Library、万方数据库、维普数据库检索自建库以来至2020年7月公开发表的有关GDF-15与DN关系的相关文献,采用Revman 5.3和Stata 12.0软件进行Meta分析。结果本研究共纳入9篇文献,Meta分析结果显示,微量白蛋白尿组GDF-15水平高于正常白蛋白尿组[SMD=0.87,95%CI:0.42~1.33,P<0.05],大量白蛋白尿组GDF-15水平高于微量白蛋白尿组[SMD=2.57,95%CI:1.01~4.13,P<0.05]和正常白蛋白尿组[SMD=3.49,95%CI:1.84~5.15,P<0.05]。结论DN患者血清GDF-15水平随其疾病严重程度加重而升高,测定GDF-15水平对判断DN病情有指导意义。Objective To explore the relationship between the level of growth differentiation factor-15(GDF-15)and staging of diabetic nephropathy by meta-analysis.Methods The articles about GDF-15 and diabetic nephropathy published from CNKI,Pubmed,Cochrane Library,Wanfang database and VIP database before July 2020 were analyzed by Revman 5.3 and Stata 12.0.Results A total of 9 articles were included in this study.Meta-analysis showed that the level of GDF-15 in microscale albuminuria group was higher than that in normal albuminuria group(SWD=0.87,95%CI:0.42~1.33,P<0.05),and GDF-15 level in macro albuminuria group was higher than that in microscale albuminuria group(SMD=2.57,95%CI:1.01~4.13,P<0.05)and normal albuminuria group(SMD=3.49,95%CI:1.84~5.15,P<0.05).Conclusion The serum GDF-15 level in diabetic nephropathy increases with the disease severity,and the determination of GDF-15 may has clinical significance.

关 键 词：糖尿病肾病 生长分化因子-15 META分析 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]