广西农村地区不同民族人群肝功能及其影响因素分析  

Analysis of liver function and its influencing factors among people with different ethnic groups in rural areas of Guangxi

作　　者：李春宏[1] 刘顺[1] 曾小云[1] 何敏[1] 苏莉[1] 黄东萍[1] 仇小强[1] LI Chun-hong;LIU Shun;ZENG Xiao-yun;HE Min;SU Li;HUANG Dong-ping;QIU Xiao-qiang(School of Public Health of Guangxi Medical University,Nanning,Guangxi 530021,China)

机构地区：[1]广西医科大学公共卫生学院,广西南宁530021

出　　处：《应用预防医学》2021年第4期290-294,310,共6页Applied Preventive Medicine

基　　金：国家重点研发计划资助项目(2017YFC0907103)。

摘　　要：目的调查广西农村地区不同民族人群的肝功能状况及其影响因素,为制订相关预防措施提供依据。方法基于"广西少数民族慢性病前瞻性队列研究"平台,于2017—2019年在广西南宁市良庆镇、那马镇等农村地区开展调查。抽取研究对象空腹静脉血5 mL,用于检测肝功能、血生化等指标。结果本次纳入调查人数13258人,来自汉、壮、瑶、侗等多个民族,平均年龄53.93岁,其中男性6562人(49.49%)、女性6696人(50.51%)。不同民族人群血清ALT(F=13.002,P<0.001)、AST(F=9.344,P<0.001)、ALP(F=7.498,P<0.001)、Tbil(F=87.426,P<0.001)水平差异有统计学意义,壮族人群较低。不同性别、不同民族人群肝功能异常率差异有统计学意义,女性(χ^(2)=485.478,P<0.001,异常率为14.4%)和壮族人群(χ^(2)=228.487,P<0.001,异常率为20.8%)较低。肝功能异常者中,59岁及以下的中青年人群占76.55%。影响ALT的因素是年龄(OR=0.969,P<0.001)、性别(OR=2.903,P<0.001)、家庭收入(OR=1.065,P=0.029)、体脂率(OR=1.010,P<0.001);影响AST的因素是性别(OR=2.037,P<0.001)、家庭收入(OR=0.930,P=0.048);影响ALP的因素是年龄(OR=1.027,P<0.001)、民族(OR=0.664,P=0.010)、家庭收入(OR=0.903,P=0.011)、体脂率(OR=1.006,P=0.003);影响Tbil的因素是性别(OR=2.723,P<0.001)、民族(OR=0.813,P=0.010)。结论广西农村地区壮族人群的主要肝功能指标水平及异常率均低于汉、侗等民族;女性肝功能指标水平较低;肝功能异常者主要是中青年个体。年龄、性别、家庭收入、体脂率是影响广西农村地区人群肝功能的主要因素。Objective To investigate the status of liver function and its influencing factors among people with different ethnic groups in rural areas of Guangxi,and to provide basis for formulating the relevant preventive measures.Methods Based on the platform of Prospective Cohort Study on Chronic Diseases of Ethnic Minorities in Guangxi,a survey was carried out in Liangqing town,Nama town,and other rural areas in Nanning city,Guangxi from 2017 to 2019.Five ml fasting venous blood was drawn from each individual and testing for liver function,blood biochemistry,and other indicators.Results Thirteen thousand two hundred and fifty-eight individuals from Han,Zhuang,Yao,Dong,and other ethnic groups were recruited,with an average age of 53.93 years old,including 6562 males(49.49%)and 6696 females(50.51%).The differences in serum ALT(F=13.002,P<0.001),AST(F=9.344,P<0.001),ALP(F=7.498,P<0.001),and Tbil(F=87.426,P<0.001)levels in different ethnic groups were statistically significant,with the lowest level of Zhuang population.There was statistically significant difference in the abnormal rate of liver function among people with different genders and ethnic groups.Female(χ^(2)=485.478,P<0.001,abnormal rate of 14.4%and Zhuang population(χ^(2)=228.487,P<0.001,abnormal rate of 20.8%)had lower rates.Among those with abnormal liver function,76.55%were the young and middle-aged people aged 59 and below.The factors affecting ALT were age(OR=0.969,P<0.001),gender(OR=2.903,P<0.001),family income(OR=1.065,P=0.029),and body fat rate(OR=1.010,P<0.001));the factors affecting AST were gender(OR=2.037,P<0.001)and family income(OR=0.930,P=0.048);the factors affecting ALP were age(OR=1.027,P<0.001),ethnicity(OR=0.664,P=0.010),family income(OR=0.903,P=0.011)and body fat rate(OR=1.006,P=0.003);factors affecting Tbil were gender(OR=2.723,P<0.001)and ethnicity(OR=0.813,P=0.010).Conclusion The abnormal rate of major liver function indexes of Zhuang population in rural areas in Guangxi are lower than Han,Dong,and other ethnic groups.Female group has low

关 键 词：肝功能 影响因素 农村地区 

分 类 号：R195[医药卫生—卫生统计学]