Fluorescent bovine serum albumin-silver nanoclusters loaded with paclitaxel can traverse the blood-brain barrier to inhibit the migration of glioma  

作　　者：Yu Liu Yu Liu Yini Zhang Weichang Xie Yalan Yang Kaigeng Hu Hongbo Xin Ping Hu Fanrong Ai 

机构地区：[1]School of Mechanical&Electronic Engineering,Nanchang University,Nanchang,Jiangxi Province,China [2]Rehabilitation Department,The Second Affiliated Hospital,Nanchang University,Nanchang,Jiangxi Province,China [3]Institute of Translational Medicine,Nanchang University,Nanchang,Jiangxi Province,China

出　　处：《Journal of Bio-X Research》2020年第4期183-192,共10页生物组学研究杂志（英文）

基　　金：funded by the National Natural Science Foundation of China(No.31960207 to FA);China Postdoctoral Science Foundation(No.2017M610402 to FA);Postdoctoral Science Foundation of Jiangxi Province of China(No.2017KY06 to FA);Nanchang Municipal Key Laboratory of 3D Bioprinting Technology and Equipment(No.2019NCZDSY001 to FA).

摘　　要：Objective::Glioma is the most common and aggressive primary brain tumor. Here, we aimed to establish a nano-drug carrier system to traverse the blood-brain barrier for the treatment and inhibition of glioma migration.Methods::The synthesis of bovine serum albumin protected-silver nanoclusters (BSA-AgNCs) was performed using chemical reduction. The drug paclitaxel (PTX) can be loaded into BSA-AgNCs through electrostatic and hydrophobic interactions to formulate spherical BSA-AgNC-PTX nanoparticles (BSA-AgNC-PTX NPs). A glioma mouse model was established by injecting U251-GFP-Luc cells into the mouse striatum, and all surgical procedures were approved by the Animal Ethics Committee of Nanchang University (SYXK2019-0003) on December 29, 2019.Results::The BSA-AgNC-PTX NPs were able to efficiently pass through the blood-brain barrier, both in vitro and in vivo, to deliver the drug to the tumor site. The in vivo assessment of BSA-AgNC-PTX NPs in glioblastoma multiforme-bearing mice revealed the significant inhibition of tumor growth and migration, prolonging the survival of the mice.Conclusion::These results indicated that BSA-AgNCs might represent an ideal nanocarrier for the treatment of glioma and has the potential to be used in the treatment of a variety of central nervous system diseases.

关 键 词：blood-brain barrier GLIOMA PACLITAXEL renal clearable silver nanoclusters 

分 类 号：R73[医药卫生—肿瘤]