硫酸羟氯喹药物不良反应文献分析  

Literature analysis on adverse reactions of hydroxychloroquine sulfate

作　　者：胡冬霞 姚瑶[2] 葛卫红[2] 于锋 HU Dongxia;YAO Yao;GE Weihong;YU Feng(School of Basic Medicine and Clinical Pharmacy,China Pharmaceutical University,Jiangsu,Nanjing 210009,China;Department of Pharmacy,Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University,Jiangsu,Nanjing 210008,China)

机构地区：[1]中国药科大学基础医学与临床药学学院,江苏南京210009 [2]南京大学医学院附属鼓楼医院药学部,江苏南京210008

出　　处：《中国医药科学》2021年第14期31-35,共5页China Medicine And Pharmacy

基　　金：江苏省医学创新团队(领军人才)(CXTDA2017041)。

摘　　要：目的探讨硫酸羟氯喹不良反应的发生特点,为其合理应用提供参考。方法检索中国知网、维普、万方、Pubmed及Embase数据库中报道硫酸羟氯喹不良反应的一次文献,检索时间为自建库起至2020年3月18日,根据纳入、排除标准对文献进行筛选,对文献归属地、患者性别、年龄、原发疾病、硫酸羟氯喹累积剂量、疗程、不良反应类型、发生时间、累及系统-器官及转归等信息进行统计分析。结果共纳入119篇文献,总计126例患者,患者男女比为8︰55,40-59岁年龄段的患者最多(37.30%),原发疾病主要为自身免疫疾病(120例,95.24%)。常见的不良反应累及系统-器官包括:皮肤及皮下组织、眼和心脏。36例患者不良反应发生时间在治疗后1月内,41例在治疗5年以上。短期治疗、累积剂量较低时皮肤及皮下组织毒性最常见,随着疗程延长、累积剂量增加,眼、心脏、肌肉骨骼和结缔组织毒性等逐渐出现。其中80例患者经停药或治疗后好转,35例未好转,11例死亡。结论使用硫酸羟氯喹时,应先注意排除有既往病史(如视网膜、心脏疾病)的患者,并监测皮肤及皮下组织、心脏系统及眼毒性,以提高用药安全性。Objective To investigate the characteristics of the occurrence of adverse reactions(ARs)of hydroxychloroquine sulfate,so as to provide reference for its rational application.Methods The primary literatures reporting ARs of hydroxychloroquine sulfate in China National Knowledge Infrastructure,China Science and Technology Journal Database,Wanfang Database,Pubmed and Embase databases were searched from the time of database construction to March 18,2020.The literatures were screened according to the inclusion and exclusion criteria,and the literature attribution,patient gender,age,primary disease,cumulative dose of hydroxychloroquine sulfate,course of treatment,type of ARs,time of occurrence,system-organ involved and regression were statistically analyzed.Results A total of 119 literatures with 126 patients were included,with a male to female ratio of 8︰55.The patients in the age group of 40-59 years were the most(37.30%),and the primary diseases were mainly autoimmune diseases(120 cases,95.24%).Common system-organ involved of ARs included skin and subcutaneous tissues,eyes and heart.ARs occurred in 36 cases within 1 month after treatment,and ARs occurred in 41 cases more than 5 years after treatment.Skin and subcutaneous tissue toxicity was most common with short-term treatment and low cumulative doses,and ocular,cardiac,musculoskeletal,and connective tissue toxicity occurred gradually with longer treatment courses and increasing cumulative doses.There were 80 cases got better after drug with drawal or treatment,35 cases did not get better,and 11 cases died.Conclusion When using hydroxychloroquine sulfate,attention should be paid to excluding patients with previous medical history(such as retinal and cardiac diseases)and monitoring skin and subcutaneous tissues,cardiac system and ocular toxicity to improve the safety of drug administration.

关 键 词：硫酸羟氯喹 药物不良反应 文献分析 皮肤及皮下组织毒性 心脏系统毒性 眼毒性 

分 类 号：R978.6[医药卫生—药品]