炒菟丝子工艺优选及质量标准研究  

Study on the Optimization and Quality Standard of Fried Cuscuta australis

作　　者：徐维茵 董坤园 李世昌 许佳明[1] 许天阳[1] 于澎[1] XU Wei-yin;DONG Kun-yuan;LI Shi-chang;XU Jia-ming;XU Tian-yang;YU Peng(Changchun University of Chinese Medicine,Changchun,Jilin 130117,China)

机构地区：[1]长春中医药大学,吉林长春130117

出　　处：《时珍国医国药》2021年第5期1130-1133,共4页Lishizhen Medicine and Materia Medica Research

基　　金：吉林省中药材地方标准项目(JLPZGF-2017-034);吉林省中医药管理局中药特色技术传承人才培训项目(吉中医药发[2018]159号)。

摘　　要：目的优选炒菟丝子炮制工艺,并建立其饮片质量标准。方法以外观性状、金丝桃苷含量为指标,采用单因素考察炒制温度、炒制时间、翻动频率,设计正交实验优选炒菟丝子工艺;对炒菟丝子饮片进行显微鉴别、薄层鉴别;检查水分、灰分;测定浸出物;采用高效液相色谱法测定指标性成分金丝桃苷含量。结果优选的炒菟丝子工艺为炒制温度(140±10)℃,炒制时间15min,翻动频率(20±5)r/min;质量标准为:水分不得过10.0%,总灰分不得过10.0%,酸不溶性灰分不得过4.0%,浸出物含量不得低于13.0%,金丝桃苷的含量不得低于为0.10%。结论优选的炒制工艺稳定可行,适用于工业化生产;建立了一套完整的质量标准,能简便、有效地控制炒菟丝子饮片质量。Objective To optimize the processing technology of Fried Cuscuta australis and establish the quality standard of its decoction pieces.Methods Using appearance traits and hyperoside content as indicators,using single factors to investigate frying temperature,frying time,and flipping frequency,orthogonal experiments were designed to optimize the process of frying dodder seeds;microscopic identification and thin-layer identification were performed on fried dodder seeds;Check its impurities,moisture,ash;determine alcohol-soluble extract;use high performance liquid chromatography to determine the content of the index component hyperoside.Results The optimal process for Fried Cuscuta australis and is as follows:frying temperature 140±10℃,frying time 15 min,turning frequency 20±5 r/min;quality standards:moisture must not exceed 10.0%,total ash must not exceed 10.0%,and acid-insoluble ash must not Over 4.0%,the extract content must not be less than 13.0%,and the hyperoside content must not be less than 0.10%.Conclusion The optimized frying process is stable and feasible,and is suitable for industrial production;a complete set of quality standards has been established,which can control the quality of fried dodder seeds simply and effectively.

关 键 词：炒菟丝子 工艺研究 质量标准 

分 类 号：R283[医药卫生—中药学]