黄芪注射液对血液透析患者静脉铁剂治疗后微炎症的影响  

Effect of Astragalus Injection on Micro-inflammation of Hemodialysis Patients After Intravenous Iron Therapy

作　　者：杜美莲 漆映辉[1] 曲晓璐[1] 张善宝[1] 王小玉[1] 乔诚 DU Mei-lian;Qi Ying-hui;QU Xiao-lu;ZHANG Shan-bao;Wang Xiao-yu;QIAO Cheng(Department of Nephrology,Punan Hospital,Pudong New District,Shanghai 200125)

机构地区：[1]上海市浦东新区浦南医院肾脏内科,上海200125

出　　处：《世界中西医结合杂志》2021年第8期1530-1532,1537,共4页World Journal of Integrated Traditional and Western Medicine

基　　金：上海市浦东新区科委项目(PKJ2016-Y05)。

摘　　要：目的观察黄芪注射液对血液透析患者铁剂治疗后微炎症的影响。方法选取2017年1月—2017年6月期间在上海市浦东新区浦南医院血液净化中心维持性血液透析患者60例,按随机数字表法分为对照组和治疗组,每组30例。两组患者除基础治疗外,治疗组予铁剂联合黄芪注射液治疗,对照组予铁剂治疗。两组患者均治疗5周后,观察比较两组患者治疗前后铁代谢指标、贫血指标包括铁(Fe)、血清铁蛋白(SF)、转铁蛋白饱和度(TSAT)、血红蛋白(Hb)水平和微炎症指标白细胞介素-6(IL-6)、血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)的变化情况。结果治疗后治疗组微炎症指标IL-6、hs-CRP、TNF-α水平较治疗前明显降低,差异有统计学意义(P<0.05);且治疗组治疗后微炎症指标IL-6、hs-CRP、TNF-α水平较对照组明显降低,两组比较,差异有统计学意义(P<0.05)。治疗后两组患者Fe、SF、TSAT、HB水平均较治疗前升高,差异有统计学意义(P<0.05);且治疗组治疗后Fe、SF、TSAT、HB水平均高于对照组,两组比较,差异有统计学意义(P<0.05)。治疗期间,两组患者无不良事件发生,大便常规加隐血试验、肝功能、心电图异常率比较,差异无统计学意义(P>0.05)。结论静脉铁剂的使用在一定程度上加重了血液透析患者的微炎症状态,黄芪注射液在改善血液透析患者铁剂治疗后微炎症状态方面发挥了一定的作用,并且使铁剂纠正贫血方面的疗效得到了提高。Objective To observe the effect of astragalus injection on microinflammation in hemodialysis patients after iron treatment.Methods A selection of 60 patients with maintenance hemodialysis in the Blood Purification Center of Punan Hospital,Pudong New Area,Shanghai from January 2017 to June 2017 were divided into a control group(iron treatment)and a treatment group(iron treatment)using a random number table.In addition to the basic treatment,the treatment group was treated with iron+astragalus injection.The control group was treated with iron for 4 weeks.After 5 weeks of treatment in both groups,the iron metabolism indexes and anemia indexes of the two groups were observed and compared before and after treatment,including iron(Fe),serum ferritin(SF),transferrin saturation(TSAT),hemoglobin(Hb)levels and Changes in micro-inflammatory indicators interleukin-6(IL-6),serum high-sensitivity C-reactive protein(hs-CRP),and tumor necrosis factor-α(TNF-α).Results After treatment,the levels of micro-inflammatory indexes IL-6,hs-CRP,and TNF-αin the treatment group were significantly lower than those before treatment,and the difference was statistically significant(P<0.05);and the micro-inflammatory indexes IL-6,hs of the treatment group after treatment-The levels of CRP and TNF-αwere significantly lower than those of the control group,and the difference between the two groups was statistically significant(P<0.05).After treatment,the levels of Fe,SF,TSAT,and HB in the two groups were higher than before treatment,and the difference was statistically significant(P<0.05);and the levels of Fe,SF,TSAT,and HB in the treatment group after treatment were higher than those in the control group.The difference between the two groups was statistically significant(P<0.05).During the treatment period,the two groups of patients had no adverse events.The stool routine plus occult blood test,liver function and electrocardiogram abnormal rate were not statistically different(P<0.05).Conclusion The use of intravenous iron agent to a certain e

关 键 词：血液透析 微炎症 静脉铁剂 黄芪注射液 

分 类 号：R459.5[医药卫生—治疗学]