养血止痛丸联合针灸治疗神经根型颈椎病患者的临床观察  被引量:17

Clinical Observation on the Treatment of Yangxue Zhitong Pill Combined with Acupuncture on Patients with Cervical Spondylotic Radiculopathy

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作  者:王秋生 赵明宇 王宁 张学珍 冯方 蔡慧珍 WANG Qiu-sheng;ZHAO Ming-yu;WANG Ning;ZHANG Xue-zhen;FENG Fang;CAI Hui-zhen(Department of Pain,Luoyang Orthopedic Hospital of Henan Province(Orthopedic Hospital of Henan Province),Luoyang Henan 450000)

机构地区:[1]河南省洛阳正骨医院(河南省骨科医院)疼痛科,河南洛阳450000

出  处:《世界中西医结合杂志》2021年第8期1546-1550,共5页World Journal of Integrated Traditional and Western Medicine

基  金:河南省中医药科学研究专项课题(2019ZYBJ23)。

摘  要:目的观察养血止痛丸联合针灸对神经根型颈椎病患者的疗效。方法选取2018年1月—2020年1月期间就诊于河南省洛阳正骨医院(河南省骨科医院)疼痛科的300例神经根型颈椎病疼痛患者作为研究对象,采用随机数表法将患者分为治疗组和对照组,每组各150例。对照组采用推拿疗法,治疗组在对照组的基础上使用养血止痛丸联合针灸治疗。治疗后对比分析两组临床疗效、中医证候积分、疼痛因子[神经肽Y(Neuropeptide Y,NPY)、环氧化酶-2(Cyclooxygenase-2,COX-2)、胰岛素样生长因子-1(Insulin-like growth factor 1,IGF-1)]、炎症因子[白介素-6(Interleukin-6,IL-6)、白介素-8(Interleukin-8,IL-8)、白介素-10(Interleukin-10,IL-10)、超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)]、血液流变学(全血高切黏度、全血低切黏度、血浆黏度、红细胞比容、纤维蛋白原)及不良反应发生情况。结果治疗1个月后,治疗组总有效率92.67%(139/150)明显高于对照组84.00%(126/150),差异有统计学意义(P<0.05)。治疗后两组患者各项中医证候积分均下降,与治疗前比较,差异有统计学意义(P<0.05);且治疗组各项中医证候积分低于对照组,两组比较,差异有统计学意义(P<0.05)。治疗后两组患者疼痛因子NPY、COX-2水平均降低、IGF-1水平均提高,与治疗前比较,差异有统计学意义(P<0.05);且治疗组NPY、COX-2降低水平、IGF-1升高水平均优于对照组,两组比较,差异有统计学意义(P<0.05)。治疗后两组患者炎症因子IL-6、IL-8、hs-CRP水平均降低、IL-10水平均提高,与治疗前比较,差异均有统计学意义(P<0.05);且治疗组IL-6、IL-8、hs-CRP降低水平、IL-10升高水平均优于对照组,两组比较,差异有统计学意义(P<0.05)。治疗后两组患者全血高切黏度、全血低切黏度、血浆黏度、红细胞比容、纤维蛋白原水平与治疗前比较均降低,差异有统计学意义(P<0.05);且治疗组各项血液流�Objective To observe the curative effect of Yangxue Zhitong pill combined with acupuncture on cervical spondylotic radiculopathy.Methods From January 2018 to January 2020,300 patients with radiculopathy pain in the Department of Pain,Luoyang Orthopedic Hospital of Henan Province(Henan Orthopedic Hospital)were selected as the research objects.All patients were randomly divided into treatment group and control group with 150 cases in each group.The control group was treated with massage therapy,and the treatment group was treated with Yangxue Zhitong pill combined with acupuncture on the basis of the control group.The clinical efficacy,TCM syndrome integral,pain factor[Neuropeptide Y(NPY),Cyclooxygenase-2(COX-2),and Insulin-like growth factor 1(IGF-1)],inflammatory factors[Interleukin-6(IL-6),Interleukin-8(IL-8),Interleukin-10(Interleukin-10,IL-10),hypersensitive C-reactive protein(hs-CRP)],hemorheology(whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity)were compared and analyzed.The incidence of adverse reactions was also observed.Results After 1 month of treatment,the total effectiverate of 92.67%(139/150)in the treatment group was significantly higher than that in the control group 84.00%(126/150),and the difference was statistically significant(P<0.05).The scores of various TCM syndromes of the two groups of patients decreased compared with those before treatment,and the difference was statistically significant(P<0.05).The scores of various TCM syndromes of the treatment group were lower than those of the control group,and the difference between the two groups was statistically significant(P<0.05).The levels of pain factors NPY and COX-2 decreased,and the level of IGF-1 increased in the two groups were statistically significant compared with those before treatment(P<0.05);and the levels of NPY,COX-2 decreased,and IGF-1 in the treatment group The increase level was better than that of the control group,and the difference between the two groups was statistically significant(P<0.05).

关 键 词:养血止痛丸 针灸 颈椎病 血液流变学 疼痛因子 炎症因子 

分 类 号:R245.31[医药卫生—针灸推拿学] R681.55[医药卫生—中医临床基础]

 

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