Identification of Half‑Sisters from Different Mothers by Autosomal and X Chromosomal Short Tandem Repeats:A Case Study  

作　　者：Jinpei Zhang Shicheng Hao Yan Liu Li Yuan 

机构地区：[1]Key Laboratory of Evidence Science(China University of Political Science and Law),Ministry of Education,Beijing,China [2]Collaborative Innovation Center of Judicial Civilization,Beijing,China

出　　处：《Journal of Forensic Science and Medicine》2021年第2期66-69,共4页法庭科学与法医学杂志（英文）

基　　金：This work was financially supported by the project of Humanities and Social Sciences Research of the Ministry of Education(No.19YJA820050).

摘　　要：Complex kinship identification such as half‑sibling identification is a difficult task in forensic biology Here we represented an approach in dealing with half‑sisters from different mothers,with the combination of autosomal and X chromosomal short‑tandem repeats(STRs)data.X chromosomal STRs can offer additional information,especially in some cases where autosomal STRs alone may not provide enough information for an accurate opinion.In this case,half‑sister or unrelated relationship between two women(S_(1)and S_(2))with different mothers were distinguished.23 autosomal and 31 X chromosomal STRs of S_(1),S_(2),S_(1)’s mother(M1),S_(2)’s mother(M2)and S_(1)’s grandmother(G1)were profiled with three different commercial kits.As to X‑chromosome STRs,likelihood ratios(LRs)were calculated by FamLinkX with consideration of linkage,linkage disequilibrium,and mutations.When only the profiles of the two individuals(S_(1)and S_(2))were available,LRs between S_(1)and S_(2)were 1.1110×10^(2)based on 23 autosomal STRs and 3.2257 om107 based on 31 X chromosomal STRs.When the maternal genotypes were taken into consideration,LRs increased to 2.5297×10^(3)and 3.0563×10^(18).Therefore,both the DNA profiles of each mothers and X chromosomal STRs are important in dealing with the identification of half‑sisters from different mothers.

关 键 词：Forensic case half‑sisters likelihood ratio short tandem repeat X chromosomal short tandem repeat 

分 类 号：D91[政治法律—法学]