甘肃不同产地黄芪药材的活性成分对比研究  

Comparative Study of Active Ingredients of Astragalus membranaceus from Different Origins in Gansu

作　　者：杨祎辰 王二欢 王继强 马存德 常晖 靳鹏博 YANG Yi-chen;WANG Er-huan;WANG Ji-qiang(Shaanxi Institute of International Trade&Commerce,Xianyang,Shaanxi 712046;Shaanxi Buchang Pharmaceutical Co.,Ltd.,Xi’an,Shaanxi 710075)

机构地区：[1]陕西国际商贸学院,陕西咸阳712046 [2]陕西步长制药有限公司,陕西西安710075

出　　处：《安徽农业科学》2021年第17期161-164,188,共5页Journal of Anhui Agricultural Sciences

基　　金：国家重点研发计划——中医药现代化研究重点专项(2017-YFC1700702);2019年医疗服务与保障能力提升补助资金(财社〔2019〕39号)。

摘　　要：[目的]通过测定不同产地黄芪的主要活性成分含量,研究不同成分间的相互关联性。[方法]收集甘肃陇西及周边共7个产地36批次黄芪样品,分别测定总糖、还原糖、总黄酮、毛蕊异黄酮葡萄糖苷、总皂苷和黄芪甲苷6种主要活性成分,对测定数据进行Pearson相关性分析并建立回归方程。[结果]36批次黄芪样品的黄芪甲苷和毛蕊异黄酮葡萄糖苷含量基本符合药典标准。黄芪的主要活性成分间呈现出一定的相关性。其中,还原糖与总糖呈极显著正相关,毛蕊异黄酮葡萄糖苷与总黄酮呈显著正相关,黄芪甲苷与还原糖呈显著负相关。[结论]该研究为进一步探讨甘肃道地药材黄芪与自然生态环境的相关性提供数据支撑和理论依据。[Objective]By measuring the content of the main active ingredients of Astragalus membranaceus from different origins,the correlation between them was studied.[Method]A total of 36 batches of Astragalus membranaceus samples from 7 producing areas in Longxi of Gansu and its surrounding areas were collected,the 6 main active components of total sugar,reducing sugar,total flavonoids,calycosin-7-glucoside,total saponins and astragaloside IV were determined,pearson correlation analysis of the measured data was performed and the regression equation was established.[Result]The contents of astragaloside IV and calycosin-7-glucoside in 36 batches of Astragalus membranaceus samples met the pharmacopoeia standards.The main active components of Astragalus membranaceus showed a certain correlation.Among them,reducing sugars had a very significant positive correlation with total sugars,calycosin-7-glucoside had a significant positive correlation with total flavonoids,and astragaloside IV had a significant negative correlation with reducing sugars.[Conclusion]This research provides data support and theoretical basis for further exploring the correlation between the authentic medicinal material Astragalus membranaceus in Gansu and the natural ecological environment.

关 键 词：黄芪 道地药材 活性成分 相关分析 不同产地 甘肃 

分 类 号：R282[医药卫生—中药学]