重度阻塞性睡眠呼吸暂停低通气综合征患者呼出气一氧化氮水平及其与涎液化糖链抗原的相关性  

Fractional exhaled nitric oxid level of patients with severe obstructive sleep apnea and hypopnea syndrome and its correlation with Krebs Von den Lungen-6

作　　者：杨家盛 孙瑞琳 王燕[1] 林国辉[1] 刘庆峰[1] 江小运[1] YANG Jia-sheng;SUN Rui-lin;WANG Yan;LIN Guo-hui;LIU Qing-feng;JIANG Xiao-yun(Department of Respiratory and Critical Care Medicine,the Second People′s Hospital of Guangdong Province,Guangzhou 510317,China)

机构地区：[1]广东省第二人民医院呼吸与危重症医学科,广东广州510317

出　　处：《中国当代医药》2021年第24期52-54,共3页China Modern Medicine

基　　金：广东省中医药局科研项目(20192003)。

摘　　要：目的探讨重度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者呼出气一氧化氮(FeNO)及其与涎液化糖链抗原(KL-6)的相关性。方法选取2017年1月—2018年12月广东省第二人民医院收治的70例重度OSAHS患者作为试验组,选择同期70例健康者作为对照组。比较两组体重指数(BMI)、呼吸暂停低通气指数(AHI)、最低血氧饱和度(LSaO_(2))、KL-6和FeNO水平,分析FeNO与BMI、AHI、LSaO_(2)、KL-6的相关性。结果试验组的BMI和AHI水平高于对照组,LSaO_(2)低于对照组,差异有统计学意义(P<0.05);试验组的KL-6和FeNO水平高于对照组,差异有统计学意义(P<0.05)。FeNO水平与BMI、AHI、KL-6呈正相关(r=0.43,0.57,0.37,P<0.05);FeNO水平与LSaO_(2)呈负相关(r=-0.49,P<0.05)。结论重度OSAHS患者血清中KL-6和FeNO水平升高,并且FeNO水平与KL-6、AHI呈正相关,与LSaO_(2)呈负相关,提示FeNO与疾病严重程度相关,可作为评估病情的指标之一。Objective To investigate fractional exhaled nitric oxid(FeNO)of patients with severe obstructive sleep apnea and hypopnea syndrome(OSAHS)and its correlation with Krebs Von den Lungen-6(KL-6).Methods From January 2017 to December 2018,a total of 70 patients with severe OSAHS admitted to the Second People′s Hospital of Guangdong Province were selected as the experimental group,and seventy healthy persons in the same period were selected as the control group.The body mass index(BMI),apnea-hypopnea index(AHI),lowest oxygen saturation(LSaO_(2)),KL-6 and FeNO levels of the two groups were compared,and the FeNO correlation with BMI,AHI,LSaO_(2),KL-6 were analysed.Results The level of BMI and AHI in the experimental group was higher than those in the control group,and the level of LSaO_(2) was lower than that in the control group,the differences were statistically significant(P<0.05).The levels of KL-6 and FeNO in the experimental group were higher than those in the control group,the differences were statistically significant(P<0.05).FeNO level was positively correlated with BMI,AHI and KL-6(r=0.43,0.57,0.37,P<0.05).There was a negative correlation between FeNO and LSaO_(2)(r=-0.49,P<0.05).Conclusion The levels of KL-6 and FeNO in patients with severe OSAHS increased,and the levels of FeNO were positively correlated with AHI and KL-6,and negatively correlated with LSaO_(2).It is suggested that FeNO is related to the severity of the disease and can be used as an index to evaluate the disease.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 涎液化糖链抗原 呼出气一氧化氮检测 气道炎症 氧化应激反应肺损伤 

分 类 号：R766[医药卫生—耳鼻咽喉科]