小檗碱治疗胶质瘤分子机制的研究进展  

Advances in molecular mechanism of berberine in treatment of glioma

作　　者：郝佳琪 何兴月 杨鑫 张裕 白皓 段虎斌[3] Hao Jiaqi;He Xingyue;Yang Xin;Zhang Yu;Bai Hao;Duan Hubin(The First Clinical School of Shanxi Medical University,Taiyuan 030001,China;Nursing School,Shanxi Medical University,Taiyuan 030001,China;Department of Neurosurgery,the First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一临床医学院,030001 [2]山西医科大学护理学院,030001 [3]山西医科大学第一医院神经外科,030001

出　　处：《肿瘤研究与临床》2021年第7期557-560,共4页Cancer Research and Clinic

基　　金：国家自然科学基金青年科学基金(30600637);中国博士后基金特别资助项目(2019T120195);山西省卫健委科技攻关项目(2019029)。

摘　　要：胶质瘤是最常见的原发性颅内肿瘤之一,占恶性脑瘤的80%。胶质瘤的常规治疗是手术切除后辅以替莫唑胺化疗,但会逐渐出现耐药情况,造成患者预后不良。小檗碱是提取自黄连的生物碱,具有广泛的药理活性,通过控制不同的分子和细胞途径,在胶质瘤中发挥其抑制肿瘤生长等药理作用。现就小檗碱在治疗胶质瘤方面的应用以及具体分子机制领域研究进展进行综述。Glioma is one of the most common primary intracranial tumors,accounting for 80%of malignant brain tumors.The conventional treatment of glioma is surgical resection followed by temozolomide chemotherapy,but the drug resistance will gradually appear that results in a poor prognosis of the patient.Berberine is an alkaloid extracted from Coptis Rhizoma,which has a wide range of pharmacological activities.It exerts its pharmacological effects on glioma such as inhibiting tumor growth through controlling different molecular and cellular pathways.In this article,the application of berberine in the treatment of glioma and the research progress of specific molecular mechanism are reviewed.

关 键 词：神经胶质瘤 小檗碱 脑肿瘤 MAP激酶信号系统 分子生物学 

分 类 号：R285[医药卫生—中药学]