红花对急性血瘀模型大鼠的活血化瘀作用研究  

Effects of safflower on promoting blood circulation and removing blood stasis in acute blood stasis model rats

作　　者：刘倩倩 王越 周婧 朱新龙 陈超 王升菊 裴瑾[1] LIU Qian-qian;WANG Yue;ZHOU Jing;ZHU Xin-long;CHEN Chao;WANG Sheng-ju;PEI Jin(Chengdu University of Traditional Chinese Medicine,Chengdu 611137,Sichuan)

机构地区：[1]成都中医药大学,四川成都611137

出　　处：《中药与临床》2021年第3期62-64,94,共4页Pharmacy and Clinics of Chinese Materia Medica

基　　金：国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人函[2019]41号);四川省中医药管理局中医药重点学科建设项目(川中医药函[2020]84号)。

摘　　要：目的:通过药效学指标检测,评价红花在活血化瘀方面的作用。方法:42只大鼠分为空白组、模型组、阿司匹林治疗组(15 mg·kg^(-1))、红花低、中、高剂量组(1000、2000、4000 mg·kg^(-1)),采用皮下注射肾上腺素结合冰水游泳复制大鼠急性血瘀模型,测定各组大鼠的血液流变学指标、凝血参数、血小板聚集率、血浆6-keto-PGF1α、血栓素B2(TXB2)和内皮型一氧化氮合酶(eNOS)含量。结果:红花高中低剂量组能不同程度降低血小板聚集率,延长凝血酶原时间(PT)和活化部分凝血酶原时间(APTT),降低全血粘度(WBV)、血浆粘度(PV),升高血清eNOS、6-keto-PGF1α,降低TXB2含量等。结论:红花通过恢复血小板聚集活性、改善凝血功能、血液流变性、血管内皮功能,抑制血栓形成等途径,对大鼠急性血瘀有较好的保护和治疗作用.Objective:To evaluate the effect of safflower on promoting blood circulation and removing blood stasis by pharmacodynamic index test.Method:42 rats were divided into control group,model group,aspirin treatment group(15 mg·kg^(-1)),safflower low,medium and high dose groups(1000 mg·kg^(-1),2000 mg·kg^(-1),4000 mg·kg^(-1)).The acute blood stasis model was established by subcutaneous injection of adrenaline and swimming in ice water.The hemorheological indexes,coagulation parameters,platelet aggregation rate,the levels of plasma 6-Keto-PGF1α,TXB2 and eNOS were measured.Result:Safflower low,medium and high dose group can reduce platelet aggregation rate,prolong prothrombin time(PT)and activated partial prothrombin time(APTT),reduce whole blood viscosity(WBV)and plasma viscosity(PV),increase serum eNOS and 6-keto-pgfla,and reduce TXB2.Conclusion:Safflower has good protective and therapeutic effects on acute blood stasis in rats by restoring platelet aggregation activity,improving coagulation function,hemorheology,vascular endothelial function and inhibiting thrombosis.

关 键 词：红花 急性血瘀 大鼠 凝血 活血化瘀 

分 类 号：R285.5[医药卫生—中药学]