30例慢性酒精中毒性周围神经病患者的临床特征分析  

Analysis of Clinical Characteristics of 30 Patients with Chronic Alcoholic Peripheral Neuropathy

作　　者：王晓娟 马艳娜 WANG Xiaojuan;MA Yanna(Department of Neurology,Nanle Zhongxing Hospital,Puyang 457400,Henan,China)

机构地区：[1]南乐中兴医院神经内科,河南濮阳457400

出　　处：《中国药物滥用防治杂志》2021年第4期479-481,共3页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:分析慢性酒精中毒性周围神经病患者的临床特征。方法:于2019年1月-2021年1月选取该院收治的慢性酒精中毒性周围神经病患者30例(A组)与非酒精所致周围神经病患者30例(B组),同时选取同时段在该院体检的30名健康者(C组),通过血生化检查、Keypoint肌电诱发电位仪和心电图测定3组维生素B1水平、胫神经传导速度、呼吸差及卧立心率,比较3组患者血浆维生素B1水平,感觉、运动以及自主神经功能评分,不良症状发生率。结果:A组感觉神经传导速度(SCV)、运动神经传导速度(MCV)、呼吸差及卧立心率水平均低于B、C组,且B组低于C组,差异有统计学意义(P<0.05);B、C组呼吸差及卧立心率无差异(P>0.05);3组研究对象血浆维生素B1水平比较,差异有统计学意义(P<0.05),且A组低于B组,差异有统计学意义(P<0.05);A组患者四肢远端麻木刺痛、双下肢远端无力、双下肢震颤觉减退、Wernick脑病发生率均高于B组患者,差异有统计学意义(P <0.05),两组共济失调发生率无差异(P> 0.05)。结论:慢性酒精中毒性周围神经病患者胫神经传导速度减慢,自主神经功能受损,血浆维生素B1水平显著降低,且四肢远端麻木刺痛、双下肢远端无力、双下肢震颤觉减退及Wernick脑病发生率增高,可能与长期摄入酒精导致神经肌肉接头的细胞毒性与营养代谢障碍有关。Objective: To analyse the clinical characteristics of patients with chronic alcoholic peripheral neuropathy. Methods: From January 2019 to January 2021, 30 patients with chronic alcoholic peripheral neuropathy(group A) and 30 patients with non-alcohol-induced peripheral neuropathy(group B) who were admitted to the hospital were selected. At the same time, they were selected for physical examination in the hospital at the same time. Of 30 healthy subjects(group C), measured the vitamin B1 level, tibial nerve conduction velocity, poor breathing and lying heart rate in the three groups through blood biochemical examination, Keypoint Evoked Potential Apparatus and electrocardiogram, the plasma vitamin B1 levels, sensory, motor and autonomic function scores, and the incidence of adverse symptoms were compared among the three groups of patients. Results: The sensory nerve conduction velocity(SCV), motor nerve conduction velocity(MCV), poor breathing, and lying heart rate levels of group A were lower than those in groups B and C, and group B were lower than those in group C, the differences were significant(P < 0.05), there was no statistically significant difference in poor breathing and lying heart rate in groups B and C(P > 0.05);comparison of plasma vitamin B1 levels among research subjects in groups A, B, and C was significantly different(P < 0.05);the numbness and tingling in the distal extremities, distal weakness of both lower extremities, decreased tremor of both lower extremities, Wernick encephalopathy of group A was higher than that of group B, and the difference was statistically significant(P<0.05). There was no significant difference in the incidence of ataxia between the two groups(P>0.05). Conclusion: In patients with chronic alcoholic peripheral neuropathy, the tibial nerve conduction velocity is slowed, the autonomic nerve function is impaired, the plasma vitamin B1 level is significantly reduced, and the distal limbs are numb and tingling, the distal limbs are weak, the tremor of the lower limbs is r

关 键 词：慢性酒精中毒 周围神经病 临床特征 心率 

分 类 号：R595.6[医药卫生—内科学] R747.9[医药卫生—临床医学]