聚乙二醇干扰素α-2a联合阿德福韦酯治疗e抗原阳性慢性乙型肝炎患者的效果  

Efficacy of Peginterferon α-2a Combined with Adefovir Dipivoxil in Patients with Chronic Hepatitis B with Positive Antigen e

作　　者：张霞 李俊红 袁方 ZHANG Xia;LI Junhong;YUAN Fang(Department of Infectious Diseases,Xuchang People’s Hospital,Xuchang 461000,China)

机构地区：[1]许昌市人民医院感染科,河南许昌461000

出　　处：《河南医学研究》2021年第23期4353-4356,共4页Henan Medical Research

摘　　要：目的探讨聚乙二醇干扰素α-2a联合阿德福韦酯治疗e抗原阳性慢性乙型肝炎患者的临床效果。方法选取许昌市人民医院2019年1—12月收治的96例e抗原阳性慢性乙型肝炎患者,按随机数表法分为观察组(48例)与对照组(48例)。两组均接受常规治疗,对照组接受阿德福韦酯治疗,观察组在对照组基础上接受聚乙二醇干扰素α-2a治疗。比较两组疗效、肝功能、炎症因子、乙型肝炎标志物及病毒水平、T细胞亚群。结果观察组治疗总有效率(91.67%)较对照组(66.67%)高(P<0.05)。治疗后观察组乙型肝炎病毒脱氧核糖核酸(HBV DNA)、乙型肝炎表面抗原(HBsAg)、总胆红素(T-Bil)、谷草转氨酶(GOT)、谷丙转氨酶(GPT)水平低于对照组,白蛋白(ALB)水平高于对照组(P<0.05)。治疗后观察组白介素(IL)-6、IL-10、CD8^(+)水平低于对照组,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、IL-2水平高于对照组(P<0.05)。结论聚乙二醇干扰素α-2a联合阿德福韦酯治疗e抗原阳性慢性乙型肝炎效果较好,可有效清除乙型肝炎病毒,促进肝功能恢复,抑制炎症反应,调节患者免疫功能。Objective To investigate the effect of peginterferonα-2 a combined with adefovir dipivoxil on patients with chronic hepatitis B with positive antigen e.Methods A total of 96 patients with e-antigen-positive chronic hepatitis B who were admitted to Xuchang People’s Hospital from January to December 2019 were selected and divided into observation group(48 cases)and control group(48 cases)according to the random number table method.Both groups received conventional treatment,the control group received adefovir dipivoxil treatment,and the observation group received peginterferonα-2 a treatment on the basis of the control group.The efficacy,liver function,inflammatory factors,hepatitis B markers and virus levels,and T cell subsets were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group(91.67%vs.66.67%,P<0.05).After the treatment,the levels of hepatitis B virus deoxyribonucleic acid(HBV DNA),hepatitis B surface antigen(HBsAg),total bilirubin(T-Bil),glutamic-oxaloacetic transaminase(GOT),glutamic-pyruvic transaminase(GPT)in observation group were lower than those in control group,and the level of albumin(ALB)was higher than that in control group(P<0.05).After the treatment,the levels of interleukin(IL)-6,IL-10,and CD8^(+)in observation group were lower than those in control group,and the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)and IL-2 were higher than those in control group(P<0.05).Conclusion The combination of peginterferonα-2 a and adefovir dipivoxil is effective in treating chronic hepatitis B with positive antigen e.It could effectively eliminate hepatitis B virus,promote the recovery of liver function,inhibit inflammation,and regulate the immune function of patients.

关 键 词：慢性乙型肝炎 E抗原 聚乙二醇干扰素Α-2A 阿德福韦酯 疗效 

分 类 号：R512.6[医药卫生—内科学]