HBV前S1抗原与HBV-DNA在判断HBV感染中的临床价值  

Analysis on clinical application value of HBV Pre-S1 antigen and HBV-DNA

作　　者：王俊[1] 安良[1] 王朋斌[1] 赵晓军 WANG Jun;AN Liang;WANG Pengbin;ZHAO Xiaojun(Department of Clinical Laboratory,Xi′an Gaoxin Hospital,Xi′an,Shaanxi 710075,China;Department of Clinical Laboratory,People′s Hospital of Tongguan County,Weinan,Shaanxi 710000,China)

机构地区：[1]西安高新医院检验科,陕西西安710075 [2]陕西省渭南市潼关县人民医院检验科,陕西渭南710000

出　　处：《检验医学与临床》2021年第17期2533-2535,2540,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨乙型肝炎病毒(HBV)前S1抗原与HBV-DNA在判断HBV感染中的临床应用价值。方法选择2017年6月至2019年3月在西安高新医院与陕西省渭南市潼关县人民医院住院的乙型肝炎患者与门诊体检者206例为研究对象,其中HBV-DNA阳性125例[41例乙型肝炎病毒e抗原(HBeAg)阳性患者纳入HBeAg阳性组,84例HBeAg阴性患者纳入HBeAg阴性组]。分析不同阳性标志物人群血清HBV前S1抗原、HBV-DNA的检测结果,比较HBeAg阳性组与HBeAg阴性组HBV前S1抗原、HBV-DNA的检测结果,以及部分乙型肝炎患者接受拉米夫定治疗前后的情况。结果治疗前,乙型肝炎病毒表面抗原(HBsAg)、HBeAg、乙型肝炎核心抗体(HBcAb)同时阳性人群中,HBV-DNA、HBV前S1抗原、HBV前S1抗原联合HBV-DNA阳性率高于其他各项标志物阳性组合阳性率,差异有统计学意义(P<0.05)。治疗前,HBeAg阳性组HBV-DNA、HBV前S1抗原、HBV前S1抗原联合HBV-DNA阳性率高于HBeAg阴性组,差异有统计学意义(P<0.05)。治疗后HBeAg、HBV前S1抗原、HBV-DNA检测阳性的例数少于治疗前,治疗后乙型肝炎病毒e抗体(HBeAb)检测阳性例数多于治疗前,差异有统计学意义(P<0.05)。结论乙型肝炎诊断中,可以将HBV前S1抗原作为判断HBV感染的重要指标。Objective To investigate the clinical value of HBV Pre-S1 antigen and HBV-DNA in the diagnosis of HBV infection.Methods From June 2017 to March 2019,206 cases of hepatitis B patients and health checker in Xi′an Gaoxin Hospital and People′s Hospital of Tongguan County were selected.Among them,125 cases were HBV-DNA positive(41 cases with positive HBeAg were included in HBeAg positive group,84 cases with negative HBeAg were included in HBeAg negative group).Analysis serum HBV Pre-S1 antigen,HBV-DNA in patients with different positive markers,compared HBV Pre-S1 antigen,HBV-DNA between HBeAg positive group and HBeAg negative group,as well as hepatitis B patients before and after lamivudine treatment.Results Before treatment,among the patients with positive HBsAg,HBeAg and HBcAb at the same time,the positive rates of HBV-DNA,HBV Pre-S1 antigen,HBV PreS1 antigen combined with HBV-DNA were higher than those in patients with other positive markers.Before treatment,the positive rates of HBV-DNA,HBV Pre-S1 antigen,HBV Pre-S1 antigen combined with HBV-DNA in HBeAg positive group were higher than those in HBeAg negative group(P<0.05).After treatment,the positive cases of HBeAg,Pre-S1 antigen and HBV-DNA were less than those before treatment(P<0.05),and the positive cases of HBeAb were more than before treatment(P<0.05).Conclusion Pre-S1 antigen could be used as an important index in the detection of hepatitis B virus.

关 键 词：乙型肝炎病毒 前S1抗原 HBV-DNA 乙型肝炎病毒E抗原 

分 类 号：R446.6[医药卫生—诊断学] R512.62[医药卫生—临床医学]