广藿香百秋李醇分子调控及合成生物学研究进展  

Research Progress on Patchoulol Molecular Regulation and Synthetic Biology in Pogostemon cablin

作　　者：张婵 姚广龙[1] 张军锋[1] 于靖[1] 杨东梅[1] 陈萍[1] 吴友根[1] ZHANG Chan;YAO Guang-long;ZHANG Jun-feng;YU Jing;YANG Dong-mei;CHEN Ping;WU You-gen(Institute of Horticulture,Hainan University,Haikou 571100)

机构地区：[1]海南大学园艺学院,海口571100

出　　处：《生物技术通报》2021年第8期55-64,共10页Biotechnology Bulletin

基　　金：国家自然科学基金项目(81860681);海南省自然科学基金(高层次人才项目)(2019RC087)。

摘　　要：百秋李醇是广藿香主要活性成分之一,也是《中国药典》中评价广藿香药材的重要指标,可通过天然提取或合成生物学工程两种方式获得。广藿香中百秋李醇含量低,是其规模化应用的瓶颈。本文从百秋李醇的合成途径、分子调控机制和合成生物学工程三方面综述近年来相关研究进展,为百秋李醇的开发与应用提供参考。Patchoulol is one of the main active components in Pogostemon cablin,and it is an important index for evaluating P.cablin in Chinese Pharmacopoeia.It can be obtained by natural extraction or synthetic biological engineering.The little amount of patchoulol in P.cablin is the bottleneck of its large-scale application.This paper reviews the research progress on patchoulol synthesis pathway,molecular regulation mechanism and synthetic biology engineering,providing reference for patchoulol development and application.

关 键 词：广藿香 百秋李醇 分子调控机制 合成生物工程 

分 类 号：S567.239[农业科学—中草药栽培]