细菌周质分子伴侣LolA研究进展  

Research Progress on Bacterial Periplasmic Chaperone LolA

作　　者：贺小丽 郭磊周 韩佳慧[2] 唐殷 袁媛 代其林[1] 平淑珍[2] 江世杰[1] HE Xiao-li;GUO Lei-zhou;HAN Jia-hui;TANG Yin;YUAN Yuan;DAI Qi-lin;PING Shu-zhen;JIANG Shi-jie(College of Life Science and Engineering,Southwest University of Science and Technology,Mianyang 621010;Biotechnology Research Institute,Chinese Academy of Agricultural Sciences,Beijing 100081;School of Life Sciences,Central South University,Changsha 410078)

机构地区：[1]西南科技大学生命科学与工程学院,绵阳621010 [2]中国农业科学院生物技术研究所,北京100081 [3]中南大学生命科学学院,长沙410078

出　　处：《生物技术通报》2021年第8期275-283,共9页Biotechnology Bulletin

基　　金：国家自然科学基金项目(31800061);国家科技重大专项(2019ZX08010-004)。

摘　　要：细菌脂蛋白是一种脂质修饰的膜蛋白,参与细胞膜合成等多种重要生理过程。脂蛋白形成过程依赖于Lol转运系统,该蛋白最先在细胞质中以前体的形式合成,然后在细胞膜上被加工为成熟脂蛋白,锚定于细菌外膜周质侧。Lol系统由LolA-E五种蛋白组成,其中脂蛋白在周质空间中依赖伴侣蛋白LolA进行转运,LolA将脂蛋白以"mouth to mouth"的方式从LolCDE转运至LolB,进而完成脂蛋白定位。重点对周质分子伴侣LolA结构、参与的转运体系及其生物学功能进行综述,旨在通过对脂蛋白转运分子机制的理解为感染性疾病的治疗提供更多的药物靶点。Bacterial lipoprotein is a lipid-modified membrane protein,which participates in many important physiological processes such as cell membrane synthesis.The formation of lipoproteins depends on the Lol transport system.The protein is first synthesized in the form of precursors in the cytoplasm,and then processed into mature lipoproteins on the cell membrane and anchored to the perimembranous sides of bacteria.Lol system is composed of 5 proteins LolA-E,among which the lipoprotein is transported by the chaperone LolA in the periplasmic space.LolA transports the lipoprotein from LolCDE to LolB in the way of"mouth to mouth",thereby completing the localization of lipoprotein.This review focuses on the structure,involved transport system and biological functions of periplasmic molecular chaperone LolA,aiming to provide more drug targets for the treatment of infectious diseases by understanding the molecular mechanism of lipoprotein transport.

关 键 词：脂蛋白 Lol转运系统 周质分子伴侣LolA 生物学功能 

分 类 号：Q936[生物学—微生物学]