皮肤修复生物3D打印的研究进展与挑战  

The research progress and challenge of 3D bioprinting for skin repairing

作　　者：连伟龙 连芩[1,2,3] 焦天 何晓宁 赵明 胡大海 万敏 Lian Weilong;Lian Qin;Jiao Tian;He Xiaoning;Zhao Ming;Hu Dahai;Wan Min(State Key Laboratory for Manufacturing System Engineering,School of Mechanical Engineering,Xi’an Jiaotong University,Xi’an,Shaanxi 710054,China;Jihua Laboratory,Foshan,Guangdong 528200,China;NMPA Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices,Xi’an,Shaanxi 710054,China;Xidian University,Xi’an,Shaanxi 710049,China;Department of Burns and Cutaneous Surgery,Xijing Hospital,Air Force Medical University,Xi’an,Shaanxi 710032,China;Shandong Quality Inspection Center for Medical Devices,NMPA Key Laboratory for Quality Evaluation of Medical and Health Materials and Biological Protective Devices,Jinan,Shandong 250101,China)

机构地区：[1]西安交通大学,机械制造系统工程国家重点实验室,陕西西安710054 [2]季华实验室,广东佛山528200 [3]国家药品监督管理局医用增材制造器械研究与评价重点实验室,陕西西安710054 [4]西安电子科技大学,陕西西安710049 [5]空军军医大学,西京医院烧伤与皮肤外科,陕西西安710032 [6]山东省医疗器械产品质量检验中心,国家药品监督管理局医用卫生材料及生物防护器械质量评价重点实验室,山东济南250101

出　　处：《光电工程》2021年第8期1-18,共18页Opto-Electronic Engineering

基　　金：工信部增材制造专项(2018YFE0207900);中国人民解放军科技计划(BWS17J036);季华实验室建设项目(X200031TM200);国家自然科学基金项目(51835010,51375371)。

摘　　要：皮肤作为人体最大的器官,有着屏障功能、免疫应答、防止水分流失和排泄废物等重要作用。大面积的严重皮肤损伤患者会由于缺乏充足的可移植皮肤而死亡。生物3D打印技术的发展为可移植皮肤的制造提供了解决办法。生物3D打印技术可以定制化制造功能性的皮肤替代品,有望解决移植皮肤短缺的困难。本文简述了皮肤创伤修复原理,比较了用于皮肤修复的生物材料墨水、细胞和主要的生物3D打印技术,分析了光电技术在3D打印皮肤上的应用潜力,并总结了生物3D打印技术在皮肤修复应用中所面临的挑战和未来的发展方向,提出了光电技术在生物3D打印中的应用需求。The skin is the largest organ of the human body,which plays an important role in barrier function,immune response,preventing water loss and excreting waste.Patients with large-scale severe skin injuries will die due to lack of adequate skin grafts.The development of 3D bioprinting technology provides a solution for the manufacture of transplantable skin.Firstly,the principles of skin wound repairing are described.Secondly,the bioinks,cells and main 3D bioprinting technologies used in skin wound repairing are compared.Then,the opto-electronic technologies involved are analyzed,and the challenges and future development of 3D bioprinting in the application of skin repair are summarized.Finally,the application requirements of opto-electronic technology in 3D bioprinting are proposed.

关 键 词：生物3D打印 皮肤 生物墨水 细胞 光电技术 

分 类 号：TP391.7[自动化与计算机技术—计算机应用技术] R318.08[自动化与计算机技术—计算机科学与技术]