用血管回声跟踪技术检测脉搏波传导速度评价大黄蛰虫丸对早期T2DM患者下肢动脉弹性的改善作用  

Evaluate the effects of Dahuang Zhechong Pill on the arterial elasticity of lower limbs in patients with early T2DM by detecting pulse wave velocity with vascular echo tracking technology

作　　者：石光煜[1] 王玉琳[2] 于国强 张雪松[1] 赵丽娜[1] 吕勃川[1] 初春 刘杨月 SHI Guangyu;WANG Yulin;YU Guoqiang;ZHANG Xuesong;ZHAO Lina;LYU Bochuan;CHU Chun;LIU Yangyue(First Hospital Affiliated to Heilongjiang University of Traditional Chinese Medicine,Harbin,Heilongjiang 150040,China;Second Hospital Affiliated to Heilongjiang University of Traditional Chinese Medicine,Harbin,Heilongjiang 150001,China)

机构地区：[1]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第二医院,黑龙江哈尔滨150001

出　　处：《国际检验医学杂志》2021年第17期2072-2075,共4页International Journal of Laboratory Medicine

基　　金：黑龙江省博士后科研项目(LBH-Q18116);黑龙江省中医药科研项目(ZHY19-002)。

摘　　要：目的探讨用血管回声跟踪(ET)技术检测的脉搏波传导速度(PWV)评价大黄蛰虫丸对早期2型糖尿病(T2DM)患者下肢动脉弹性的改善作用。方法选择黑龙江中医药大学附属第一医院2019年10月至2020年6月收治的早期T2DM患者60例作为研究组,然后用随机数字表法将研究组患者又分为A组和B组(各30例)。A组给予大黄蛰虫丸加基础治疗,后者给予安慰剂加基础治疗。另选择同期体检健康者30例作为对照组。上述各组均采用ET技术检测腘动脉PWV评估患者下肢动脉弹性,并进行凝血功能和血脂相关指标检测。结果A、B两组患者治疗前后血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)和高密度脂蛋白胆固醇(HDL-C)水平均短于或低于对照组(P<0.05),纤维蛋白原(FIB)、D-二聚体、总胆固醇(TC)、三酰甘油(TG)和低密度脂蛋白胆固醇(LDL-C)水平和腘动脉PWV均高于对照组(P<0.05),A组患者治疗后PT、APTT、TT和HDL-C水平明显延长或升高(P<0.05),FIB、D-二聚体、TC、TG和LDL-C水平以及PWV明显降低(P<0.05),且变化幅度均大于B组(P<0.05)。结论用ET技术检测PWV可评估患者下肢动脉弹性变化,大黄蛰虫丸有助于改善早期T2DM患者下肢动脉弹性。Objective To study the effects of Dahuang Zhechong Pill(DZP)on lower limb artery elasticity in patients with early type 2 diabetes mellitus(T2DM)evaluated by pulse wave velocity(PWV)with vascular echo tracking(ET)technique.Methods Sixty patients with early T2DM who were admitted to First Hospital Affiliated to Heilongjiang University of Traditional Chinese Medicine from October 2019 to June 2020 were enrolled as study group.Which were divided into group A and B by using random number table,30 cases in each group.The group A was treated with DZP+basic therapy,while the group B was treated with placebo+basic therapy.Meanwhile 30 healthy people who had undergone physical examination in the hospital were enrolled as the control group.All the groups underwent ET technique examination in this hospital.The vessel wall elasticity of lower limb artery was evaluated by PWV.The related coagulation function and blood lipid detection were conducted.Results Before and after treatment,plasma prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),and high-density lipoprotein cholesterol(HDL-C)in groups A and B were shorter or lower than those in control group,while levels of fibrinogen(FIB),D-dimer,total cholesterol(TC),triglyceride(TG)and low-density lipoprotein cholesterol(LDL-C),PWV of popliteal artery were higher than those in control group.After treatment,PT,APTT,TT and HDL-C significantly extended or increased(P<0.05),while levels of FIB,D-dimer,TC,TG,LDL-C,and PWV significantly decreased(P<0.05)in group A,and the amplitude of changes in group A was higher than those in group B(P<0.05).Conclusion PWV measured by using ET technique can be used to evaluate the changes in vessel wall elasticity of lower limb artery.DZP can help to improve the vessel wall elasticity of lower limb artery in patients with early T2DM.

关 键 词：血管回声跟踪技术 脉搏波传导速度 大黄蛰虫丸 2型糖尿病 下肢动脉弹性 

分 类 号：R446.1[医药卫生—诊断学]