肺移植术后气道吻合口狭窄的诊治进展  

Diagnosis and treatment progress on airway anastomotic stenosis after lung transplantation

作　　者：刘明昭 史灵芝[1] 杨航[1] 卫栋[1] 范立[1] 吴波[1] 陈静瑜[1] Liu Mingzhao;Shi Lingzhi;Yang Hang;Wei Dong;Fan Li;Wu Bo;Chen Jingyu(Wuxi People's Hospital Affiliated to Nanjing Medical University,Wuxi Lung Transplant Center,Jiangsu Lung Transplant Center,Wuxi 214000,China)

机构地区：[1]南京医科大学附属无锡市人民医院无锡市器官移植研究院江苏省肺移植中心,江苏无锡214000

出　　处：《器官移植》2021年第5期533-538,共6页Organ Transplantation

基　　金：江苏省科教强卫项目(JCRCB2016003);无锡市社会发展科技示范工程项目(WX18IVJN015)。

摘　　要：肺移植是治疗多数终末期肺病的唯一有效手段,而气道吻合口并发症是限制肺移植受者术后存活及生存质量的主要障碍。气道吻合口狭窄是肺移植术后最常见的气道吻合口并发症。近年来,受者选择、器官保存、外科技术、术后重症监护管理、免疫抑制、抗真菌及内镜治疗等方面的改进,降低了气道吻合口狭窄的发生率,改善了肺移植手术结果和受者生存情况。现就肺移植术后气道吻合口狭窄的病因及危险因素、诊断与治疗进行综述,为临床研究和诊疗肺移植术后气道吻合口狭窄提供新的思路。Lung transplantation is the only effective treatment of most end-stage lung diseases.Airway anastomotic complications are the main obstacles affecting the postoperative survival and quality of life of lung transplant recipients.Airway anastomotic stenosis is the most common airway anastomotic complication after lung transplantation.In recent years,improvements in the recipient selection,organ preservation,surgical techniques,postoperative intensive care management,immunosuppression,antifungal and endoscopic treatment have decreased the incidence of airway anastomotic stenosis and improved the surgical efficacy of lung transplantation and the survival of the recipients.In this article,the pathogenesis,risk factors,diagnosis and treatment of airway anastomotic stenosis after lung transplantation were reviewed,aiming to provide novel ideas for clinical research,diagnosis and treatment of airway anastomotic stenosis following lung transplantation.

关 键 词：肺移植 气道吻合口并发症 气道吻合口狭窄 支气管狭窄 中央气道狭窄 远端气道狭窄 支气管内扩张 支架植入 

分 类 号：R617[医药卫生—外科学] R619[医药卫生—临床医学]