低温双通道氧合机械灌注在离体劈离式肝移植中的应用  

Application of dual hypothermic oxygenated machine perfusion in ex vivo split liver transplantation

作　　者：任钧楷 张彤[1] Ren Junkai;Zhang Tong(Department of Hepatic Surgery,Liver Transplantation Center,the Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,China)

机构地区：[1]中山大学附属第三医院肝脏外科暨肝移植中心,广州510630

出　　处：《器官移植》2021年第5期550-555,共6页Organ Transplantation

基　　金：广东省自然科学基金(2019A1515011850)。

摘　　要：随着劈离式肝移植的飞速开展,其技术日趋成熟。离体劈离时,由于细胞内能量来源[如三磷酸腺苷(ATP)]的耗竭以及其他代谢紊乱,导致细胞损伤和功能障碍,这种损伤会因肝移植再灌注损伤而加重,临床上表现为移植术后并发症和移植失败。为了进一步改善离体劈离式肝移植的供肝质量,国内外研究团队使用机械灌注来改善供肝质量。本文结合了国际上离体劈离式肝移植供肝机械灌注的研究进展,阐述了低温双通道氧合机械灌注(D-HOPE)在离体劈离式肝移植中的应用和未来发展方向,旨在为增加离体劈离式肝移植的供肝来源,进一步改善供肝短缺的现状提供参考。The technology of split liver transplantation is becoming increasingly mature with rapid development.During ex vivo splitting,the depletion of intracellular energy sources[such as adenosine triphosphate(ATP)]and other metabolic disorders may lead to cell damage and dysfunction,which will be aggravated by reperfusion injury of liver transplantation,clinically manifested as postoperative complications and transplantation failure.To further improve the quality of donor liver in ex vivo split liver transplantation,research teams at home and abroad apply machine perfusion to enhance the quality of donor liver.In this article,the research progresses worldwide on machine perfusion of donor liver in ex vivo split liver transplantation were reviewed,and the application and prospect of dual hypothermic oxygenated machine perfusion(D-HOPE)in ex vivo split liver transplantation were elucidated,aiming to provide reference for increasing the source of donor liver for ex vivo split liver transplantation and further resolving the current status of donor liver shortage.

关 键 词：劈离式肝移植 供肝保存 机械灌注 低温双通道氧合机械灌注 缺血-再灌注损伤 静态冷保存 扩大标准供者 心脏死亡器官捐献 

分 类 号：R617[医药卫生—外科学]