即食型乳酸菌缓解奥利司他引起的胃肠道不良反应研究  

Study on Relieving Gastrointestinal Adverse Reactions Caused by Orlistat by Ready to Instant Lactic Acid Bacteria

作　　者：刘瑞珍 赵金伟 丁来荣 赵利枝 姚景春 张贵民 LIU Rui-zhen;ZHAO Jin-wei;DING Lai-rong;ZHAO Li-zhi;YAO Jing-chun;ZHANG Gui-min(National Engineering and Technology Research Center of Chirality Pharmaceutical,Lunan Pharmaceutical Group Co.,Ltd.,Linyi 276000,China)

机构地区：[1]鲁南制药集团股份有限公司国家手性制药工程技术研究中心,临沂276000

出　　处：《中国合理用药探索》2021年第8期89-93,共5页Chinese Journal of Rational Drug Use

摘　　要：目的:考察即食型乳酸菌对服用奥利司他引起的脂肪泻、腹泻、腹痛等胃肠道不良反应的缓解作用。方法:纳入2017年1月~2019年8月公开招募自愿参与的减肥志愿者120例,按照随机数字表法分为试验组与对照组,各60例。对照组给予奥利司他胶囊,试验组在对照组基础上给予即食型乳酸菌(舒尔佳伴侣)。观察比较两组用药前和用药后肥胖指标[身体质量指数(BMI)、腰围、臀围]、肠道菌群(有益菌、中性菌、有害菌)的变化,以及用药期间脂肪泻、腹胀、腹鸣、腹泻、腹痛等胃肠道不良反应发生情况。结果:用药后,两组BMI、腰围、臀围小于用药前,且试验组小于对照组(P<0.05)。用药后,两组志愿者有益菌(双歧杆菌、乳酸菌、Akkermansia muciniphila、柔嫩梭菌、多形拟杆菌)和中性菌(肠杆菌科)含量高于用药前、有害菌(具核梭杆菌、空肠弯曲杆菌)含量低于用药前,且试验组有益菌和中性菌含量高于对照组、有害菌含量低于对照组(P<0.05)。用药期间,试验组脂肪泻、腹胀、腹鸣、腹泻、腹痛等胃肠道不良反应发生率低于对照组(P<0.05)。结论:即食型乳酸菌可有效改善肠道菌群,缓解奥利司他引起的胃肠道不良反应,提高减肥效果。Objective:To investigate the relief effect of instant lactic acid bacteria on gastrointestinal adverse reactions such as fat diarrhea,diarrhea and abdominal pain caused by orlistat.Methods:A total of 120 weight-loss volunteers recruited from January 2017 to December 2020 were included.According to the random number table method,they were divided into test group and control group,with 60 cases in each group.The control group was given orlistat capsule,and the test group was given instant lactic acid bacteria(shuerjia mate)on the basis of the control group.The changes of obesity indexes[body mass index(BMI),waist circumference and hip circumference],intestinal flora(beneficial bacteria,neutral bacteria and harmful bacteria)and gastrointestinal adverse reactions such as fat diarrhea,abdominal distension,abdominal ringing,diarrhea and abdominal pain were observed and compared between the two groups before and after treatment.Results:After administration,the BMI,waist circumference and hip circumference of the two groups were less than those before treatment,and those of the test group were lower than those of the control group(P<0.05).After administration,the contents of beneficial bacteria(Bifidobacterium,Lactobacillus,Akkermansia Muciniphila,Clostridium tenderum,Bacteroidetes polyformis)and neutral bacteria(Enterobacteriaceae)in the two groups were higher than those before treatment,the contents of harmful bacteria(Clostridium nucleatum and Campylobacter jejuni)were lower than those before treatment,and the contents of beneficial bacteria and neutral bacteria in the test group were higher than those in the control group,the content of harmful bacteria in the test group was lower than that in the control group(P<0.05).During the treatment period,the incidence of gastrointestinal adverse reactions such as fat diarrhea,abdominal distension,abdominal ringing,diarrhea and abdominal pain in the test group was lower than that in the control group(P<0.05).Conclusion:Instant lactic acid bacteria can effectively improve inte

关 键 词：即食型乳酸菌 奥利司他胶囊 胃肠道不良反应 肠道菌群 减肥 

分 类 号：R969.3[医药卫生—药理学]