PRRSV诱导炎症及氧化应激的研究进展  

Progress in research on inflammation and oxidative stress induced by PRRSV

作　　者：张文涛 郭艳余 黄金海 张蕾 ZHANG Wen-tao;GUO Yan-yu;HUANG Jin-hai;ZHANG Lei(School of Life Science,Tianjin University,Tianjin 300072,China)

机构地区：[1]天津大学生命科学学院,天津300072

出　　处：《湖北农业科学》2021年第16期9-14,共6页Hubei Agricultural Sciences

基　　金：国家重点基础研究发展计划(973计划)资助项目(2016YFD0500305);天津自然科学基金项目(17JCZDJC33900)。

摘　　要：猪繁殖与呼吸综合症病毒(PRRSV)是一种能够引起母猪繁殖障碍和仔猪呼吸道疾病的单股正链RNA病毒,PRRSV对全球养猪业造成了严重的打击和巨大的经济损失。PRRSV感染仔猪可以引起严重的系统性炎症、间质性肺炎和发热等症状,说明炎症反应在PRRSV感染的致病机制中起重要作用。PRRSV感染后,细胞会产生过量的活性氧自由基,造成发炎组织中致病性氧化损伤,说明氧化应激反应在PRRSV感染的致病机制中也同样重要。为了进一步研究PRRSV感染的致病机制,做好PRRSV感染的预防和控制,对PRRSV引起炎症和氧化应激反应的分子机制进行了综述。Porcine Reproductive and Respiratory Syndrome Virus(PRRSV)is a single stranded positive-sense RNA virus that couldcsused reproductive disorders of sows and serious respiratory diseases in piglets.PRRSV had led to a great shock and a huge eco⁃nomic loss to the global swine industry.Severe systemic inflammation,interstitial pneumonia and fever were induced by PRRSV in pig⁃lets,indicating that the inflammatory response played an important role in the pathogenic mechanism of PRRSV infection.Cells infect⁃ed by PRRSV would produce excessive reactive oxygen species,which caused pathogenic oxidative damage in the inflamed tissue,demonstrating that oxidative stress response was also crucial in the pathogenic mechanism of PRRSV infection.In order to further ex⁃plore the pathogenic mechanism of PRRSV infection and to prevent and control PRRSV infection,this paper reviewed the molecular mechanism of inflammation and oxidative stress induced by PRRSV.

关 键 词：猪繁殖与综合征病毒 炎症 炎性细胞因子 氧化应激 活性氧 

分 类 号：Q932[生物学—微生物学]