儿童用医疗机构制剂的生产和使用现状调查分析  

Investigation and analysis of the current situation of production and clinical use of children's preparations in medical institutions

作　　者：钟旭丽[1] 韩容[2] 刘霄峰[3] 柳芳[4] 金慧臻[5] 许馨文 王翔岩[1] 赵志刚[2] 张君莉[1] ZHONG Xu-li;HAN Rong;LIU Xiao-feng;LIU Fang;JIN Hui-zhen;XU Xin-wen;WANG Xiang-yan;ZHAO Zhi-gang;ZHANG Jun-li(Department of Pharmacy,Children's Hospital of Capital Institute of Pediatrics,Beijing 100020,China;Department of Pharmacy,Beijing Tiantan Hospital Affiliated to Capital Medical University,Beijing 100050,China;Department of Pharmacy,Shanxi Children's Hospital,Taiyuan 030013,China;Department of Pharmacy,China-Japan Friendship Hospital,Beijing 100029,China;Department of Pharmacy,Children's Hospital of Soochow University,Jiangsu Suzhou 215000,China;Safe Medication for Children Branch of China Medical News and Infor Mation Association,Beijing 101200,China)

机构地区：[1]首都儿科研究所附属儿童医院药学部,北京100020 [2]首都医科大学附属北京天坛医院药学部,北京100050 [3]山西省儿童医院药学部,太原030013 [4]中日友好医院药学部,北京100029 [5]苏州大学附属儿童医院药学部,江苏苏州215000 [6]中国医药新闻信息协会儿童安全用药分会,北京102200

出　　处：《临床药物治疗杂志》2021年第8期85-89,共5页Clinical Medication Journal

基　　金：中国医药新闻协会儿童安全用药分会立项研究课题(20190002)。

摘　　要：目的调查国内部分医疗机构儿童用医疗机构制剂(简称儿童制剂)的种类、临床应用现状和需求情况,明确目前国内医疗机构制剂中适合儿童使用的品种及主要治疗领域、适宜的剂型,为儿童药品的开发与研究提供参考。方法本研究采用问卷调查法,问卷内容包括所调查医疗机构和制剂室的基本情况、医疗机构生产或使用儿童制剂的基本情况以及临床使用情况和需求。调研数据主要采用描述性分析,并采用方差分析法进行统计分析。结果本次调查共获取有效调查问卷91份,其中58家医疗机构临床在用的制剂中有儿童适用的品种。结果显示,每家医疗机构配制的儿童制剂品种数为1~33种,平均(6.95±7.66)种;被调查医疗机构儿童制剂品种数多达数百种,主要以儿童最适用的口服液体剂型为主,同时也覆盖了散剂、颗粒剂、外用膏剂、滴鼻剂及滴耳剂等儿童常用剂型;儿童制剂临床用量大的优势品种主要集中于皮肤科和呼吸科用药;由于市场供应不足,临床最希望从其他医疗机构调拨的品种主要是水合氯醛,皮肤科用药如湿疹类药膏、鞣酸软膏等,呼吸科用药如止咳化痰平喘类中成药等。结论医疗机构制剂在弥补儿童药品市场供应不足方面发挥了较大作用,但目前临床供应仍不能满足需求,可通过建立区域性的医疗机构制剂生产中心或对临床需求量大的制剂品种进行二次开发,转化成新药等措施解决问题。Objective This study was conducted to investigate the types,current situation of clinical application and de⁃mand of children's preparations in China and clarify the suitable varieties,main treatment fields and suitable dosage forms of hospital preparations for children in order to provide reference for the development and research direction of children's drugs.Methods Questionnaires were used to investigate the basic information of the investigated medical institutions and preparation departments,and the current situation of clinical application and demand of children's preparations.Descriptive statistical analysis and variance analysis were used to analyze the survey data.Results A total of 91 valid questionnaires were obtained in this survey.Among them,58 medical institutions currently use preparations suitable for children,and each medical institu⁃tion has 1 to 33 kinds of preparations for children with an average of(6.95±7.66)kinds.There are hundreds of kinds of chil⁃dren's preparations,mainly including oral liquid dosage forms suitable for children,and also covering the commonly dosage forms for children,such as powder,granule,topical plaster,nasal drops,ear drops,etc.The dominant varieties with large clinical consumption of children's preparations were mainly used in dermatology and respiratory medicine.The market is in short supply,and the varieties most expected to be allocated from other medical institutions are chloral hydrate,dermatology drugs such as eczema ointment and tannic acid ointment,and some Chinese patent medicines respiratory drugs used for the treatment of cough,phlegm and asthma.Conclusion Hospital preparations play a great role in making up for the shortage of children's medicines market supply,but the current clinical supply still can not meet the demand.The problem can be solved by establishing a regional preparation production center or carrying out the secondary development of preparation varieties with large clinical demand.

关 键 词：医疗机构 制剂 儿童 

分 类 号：R720.5[医药卫生—儿科]