细菌生物被膜耐药机制及天然药物干预的研究进展  

Research advances in drug resistance mechanisms of bacterial biofilm and natural drug intervention

作　　者：韩飞[1] 袁子添 梁新丽 熊耀坤 杨明 马广强[3] HAN Fei;YUAN Zi-tian;LIANG Xin-li;XIONG Yao-kun;YANG Ming;MA Guang-qiang(School of Pharmacy,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China;Key Laboratory of Modern Preparation of TCM of Ministry of Education,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China;Life Sciences College,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China)

机构地区：[1]江西中医药大学药学院,江西南昌330004 [2]江西中医药大学现代中药制剂教育部重点实验室,江西南昌330004 [3]江西中医药大学生命科学学院,江西南昌330004

出　　处：《中国中药杂志》2021年第14期3560-3565,共6页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81560659,81860771);江西省教育厅科学技术研究项目(GJJ201219,GJJ170722);江西省卫生计生委中医药科研计划课题(2018B139);江西中医药大学博士科研启动基金项目(2018WBZR011);大学生创新创业训练计划项目(202010412143)。

摘　　要：细菌在一定条件下形成生物被膜产生耐药性,使得抗菌剂失效甚至无效。因此,消除细菌生物被膜逆转其耐药性是目前药学领域研究的热点。近年来,有大量研究表明细菌生物被膜形成的机理复杂,影响因素众多,耐药性极强。故该文对生物被膜的形成过程、天然药物干预的方法进行了较为全面的综述,希望为生物被膜及细菌耐药性的相关研究提供一定的参考和依据。Drug resistance resulting from bacterial biofilms can invalidate antibacterial agents.Therefore,eradicating bacterial biofilms to reverse drug resistance is a hotspot in the pharmaceutical research.In recent years,numerous studies have revealed the complicated mechanism of bacterial biofilm formation and strong drug resistance with multiple influential factors involved.This paper gives a comprehensive review on the process of biofilm formation and intervention by natural drugs,which can provide some reference and evidence for the following studies.

关 键 词：细菌 生物被膜 耐药性 机制 天然药物 

分 类 号：R446.5[医药卫生—诊断学]