益气养血法对消化道肿瘤化疗后血细胞及凝血功能的影响  

Effect of replenishing qi and nourishing blood method on blood cell and coagulation function of digestive tract tumor after chemotherapy

作　　者：黄仁宝[1] 周晋华[1] 李崇慧[1] HUANG Renbao;ZHOU Jinhua;LI Chonghui(Oncology Department,The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230038)

机构地区：[1]安徽中医药大学第一附属医院肿瘤科,安徽合肥230038

出　　处：《湖北中医药大学学报》2021年第4期64-66,共3页Journal of Hubei University of Chinese Medicine

基　　金：安徽省卫生厅中医药科研项目(项目编号:2012zy25)。

摘　　要：目的观察益气养血法对消化道肿瘤化疗后血细胞及凝血功能的影响。方法将我院行化疗的62例消化道肿瘤患者随机分为治疗组与对照组各31例。对照组仅接受常规奥沙利铂+替吉奥(SOX)化疗方案,治疗组在对照组化疗基础上服用中药方剂益气养血汤,对比两组消化道肿瘤患者化疗前后血细胞、凝血功能指标变化情况。结果化疗后,治疗组患者白细胞(WBC)、红细胞(RBC)、血红蛋白(Hb)水平与化疗前比较无明显差异(P>0.05),但对照组WBC较化疗前明显降低(P<0.05),而Hb、RBC水平无明显变化(P>0.05)治疗组纤维蛋白原(FIG)、血小板(PLT)水平较化疗前明显降低(P<0.05),而凝血酶原时间(PT)、部分活化凝血活酶时间(APTT)与化疗前比较无明显差异(P>0.05),对照组化疗后FIG较化疗前明显升高(P<0.05),而其他凝血功能指标比较无显著差异(P>0.05);治疗组肿瘤缓解率与疾病控制率略高于对照组,但无统计学意义(P>0.05);治疗组化疗过程中及化疗后不良反应发生率明显低于对照组(P<0.05)。结论益气养血法配合常规化疗可有效改善消化道肿瘤患者化疗后血液高凝状态并可有效预防白细胞下降、血红蛋白下降、血小板下降及化疗不良反应的发生,且对改善患者躯体功能具有积极作用,具有应用及推广价值。Objective To observe the effect of replenishing qi and nourishing blood method on blood cell and coagulation function of gastrointestinal cancer after chemotherapy.Methods A total of 62 patients with digestive tract tumor were randomly divided into treatment group and control group with 31 cases in each group.Control group only received conventional XELOX chemotherapy,while treatment group took Yiqi Yangxue Decoction on the basis of chemotherapy.The changes of blood cells and coagulation function indexes were compared between the two groups before and after chemotherapy.Results There was no significant difference in the levels of white blood cell(WBC),red blood cell(RBC) and hemoglobin(Hb) in treatment group after chemotherapy(P>0.05),but the WBC of control group was significantly lower than that before chemotherapy(P<0.05),the levels of fibrinogen(FIG) and blood platelet(PLT) in treatment group significantly lower than those before chemotherapy(P<0.05),while prothrombin time(PT) and partial activated thrombin time(APTT) were not significantly different from those before chemotherapy(P>0.05);there was no significant difference in coagulation function between the two groups before and after chemotherapy(P>0.05),the tumor remission rate and disease control rate in treatment group were slightly higher than those in control group,but there was no statistical significance(P>0.05),the incidence of adverse reactions during and after chemotherapy in treatment group was significantly lower than that in control group(P<0.05).Conclusion Replenishing qi and nourishing blood method combined with conventional chemotherapy can effectively improve the hypercoagulable state of patients with gastrointestinal cancer after chemotherapy,and can effectively prevent the occurrence of leukopenia,hemoglobin decline,thrombocytopenia and adverse reactions of chemotherapy.

关 键 词：消化道肿瘤 益气养血法 化疗 血细胞变化 凝血功能 肿瘤缓解率 

分 类 号：R259[医药卫生—中西医结合]