Toll-like receptor 3(TLR3)regulation mechanisms and roles in antiviral innate immune responses  

作　　者：Yujuan CHEN Junhong LIN Yao ZHAO Xianping MA Huashan YI 

机构地区：[1]College of Veterinary Medicine,Southwest University,Chongqing 402460,China [2]Chongqing Veterinary Science Engineering Research Center,Chongqing 402460,China [3]Immunology Research Center,Medical Research Institute,Southwest University,Chongqing 402460,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2021年第8期609-632,共24页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：supported by the National Key R&D Program of China(No.2018YFD0501705);the Chongqing Basic Research Program(No.cstc2018jcyj AX0615);the Fundamental Research Funds for the Central Universities(Nos.XDJK2018C059 and XDJK2018C060),China。

摘　　要：Toll-like receptor 3(TLR3)is a member of the TLR family,mediating the transcriptional induction of type I interferons(IFNs),proinflammatory cytokines,and chemokines,thereby collectively establishing an antiviral host response.Studies have shown that unlike other TLR family members,TLR3 is the only RNA sensor that is utterly dependent on the Tollinterleukin-1 receptor(TIR)-domain-containing adaptor-inducing IFN-β(TRIF).However,the details of how the TLR3-TRIF signaling pathway works in an antiviral response and how it is regulated are unclear.In this review,we focus on recent advances in understanding the antiviral mechanism of the TRIF pathway and describe the essential characteristics of TLR3 and its antiviral effects.Advancing our understanding of TLR3 may contribute to disease diagnosis and could foster the development of novel treatments for viral diseases.

关 键 词：Toll-like receptor 3(TLR3) Toll-interleukin-1 receptor(TIR)-domain-containing adaptor-inducing interferon-β(TRIF) Innate immune Antiviral response 

分 类 号：R392[医药卫生—免疫学]