瑞格列奈对2型糖尿病患者血糖、胰岛素及血脂水平的影响  

Effect of repaglinide on glycolipids,insulin and lipids level in type 2 diabetic patients

作　　者：于辉 李凤华[2] 孙士杰 陈美玲[2] 勾育松 YU Hui;LI Fenghua;SUN Shijie(School of Medicine and Nursing,Dezhou University,Shandong Province,Dezhou 253006,China;不详)

机构地区：[1]德州学院医药与护理学院,253006 [2]山东省德州市人民医院,253006 [3]山东省武城县武城镇医院内科,253300

出　　处：《临床合理用药杂志》2021年第25期24-26,29,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察瑞格列奈对2型糖尿病(T2DM)患者血糖、胰岛素及血脂水平的影响。方法选取2018年3月1日-2020年2月28日德州市人民医院就诊的T2DM患者160例为研究对象,按照随机数字表法分为瑞格列奈组和格列齐特组,每组80例。患者入组后抽取空腹静脉血进行血糖、胰岛素、三酰甘油和总胆固醇检测,给予试验标准餐和相应标准治疗(给予瑞格列奈片、格列齐特缓释片)后再次检测,比较2组患者治疗前后血糖、胰岛素、空腹三酰甘油和总胆固醇水平。结果治疗6周后,2组患者空腹血糖、餐后30 min和餐后2 h血糖水平均较治疗前下降(P<0.01),但2组间水平比较差异无统计学意义(P>0.05)。瑞格列奈组治疗后空腹胰岛素水平高于治疗前,差异有统计学意义(P<0.05),但格列齐特组治疗前后及2组间空腹胰岛素比较差异均无统计学意义(P>0.05);治疗6周后2组患者餐后30 min和餐后2 h胰岛素水平均较治疗前明显升高(P<0.01),且瑞格列奈组高于格列齐特组(P<0.01)。治疗6周后,瑞格列奈组患者三酰甘油、总胆固醇水平均较治疗前降低(P<0.01),且瑞格列奈组三酰甘油水平低于格列齐特组(P<0.05),格列齐特组患者治疗前后三酰甘油、总胆固醇水平比较差异无统计学意义(P>0.05)。结论瑞格列奈可明显降低T2DM患者血糖、三酰甘油和总胆固醇水平,升高胰岛素分泌水平,有效控制血糖,延缓患者心血管动脉粥样硬化。Objective To observe the effect of repaglinide on glycolipids,insulin and lipids level in type 2 diabetic patients(T2 DM).Methods 160 patients with T2 DM who were treated in Dezhou People’s Hospital from March 1,2018 to February 28,2020 were selected as the research objects,and they were divided into repaglinide group and gliclazide group according to the random number table method,with 80 in each group.After the patients were enrolled,fasting tests were performed on blood glucose,insulin level,fasting triglycerides and total cholesterol.The experimental standard meal and standard treatment were given,and the patient’s blood glucose and insulin level were respectively measured,and the patient’s triglyceride and total cholesterol were detected after the treatment.The changes in blood glucose,insulin level,fasting triglycerides and total cholesterol before and after treatment were compared between the two groups.Results After 6 weeks of treatment,the fasting blood glucose,30 minutes after meal and 2 hours postprandial blood glucose levels in the two groups were lower than before treatment(P<0.01),but there was no significant difference in the levels between the two groups(P>0.05).The fasting insulin level after treatment in the repaglinide group was higher than before treatment,and the difference was statistically significant(P<0.05),but there was no significant difference in the gliclazide group before and after treatment between the two groups(P>0.05).After 6 weeks of treatment,the insulin levels of the two groups of patients at 30 minutes and 2 hours after the meal were significantly higher than those before the treatment(P<0.01),and the repaglinide group was higher than the gliclazide group(P<0.01).After 6 weeks of treatment,the levels of triglycerides and total cholesterol in the repaglinide group were lower than before treatment(P<0.01),and the triglyceride levels in the repaglinide group were lower than those in the gliclazide group(P<0.05),there was no significant difference in triacylglycerol and tot

关 键 词：2型糖尿病 瑞格列奈片 格列齐特缓释片 血糖 胰岛素 三酰甘油 总胆固醇 

分 类 号：R587.1[医药卫生—内分泌]