DNA感受器AIM2在肿瘤中的作用研究进展  

Research progress of DNA sensor AIM2 in the development of various tumors

作　　者：王小丽[1] 江茜 谢璐 刘志平[1,3] WANG Xiao-li;JIANG Xi;XIE Lu;LIU Zhi-ping(School of Basic Medicine,Gannan Medical University,Ganzhou,Jiangxi 341000;Grade 2020 PhD Candidate in Immunology Chinese Medical University,Shengyang,Liaoning 110122;Center for Immunology,Gannan Medical University,Ganzhou,Jiangxi 341000)

机构地区：[1]赣南医学院基础医学院,江西赣州341000 [2]中国医科大学,辽宁沈阳110122 [3]赣南医学院炎症与免疫中心,江西赣州341000

出　　处：《赣南医学院学报》2021年第8期838-843,共6页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：国家自然科学基金项目(31960163);江西省自然科学基金项目(20171ACB20024,20181BAB205032);赣南医学院科技创新团队项目(TD201703)。

摘　　要：DNA感受器黑色素瘤缺乏因子(AIM2)作为启动固有免疫应答的胞内DNA模式识别受体,能够特异性识别病原体释放入胞浆中的dsDNA,通过组装炎症小体调控细胞焦亡与炎性细胞因子的分泌。近年研究发现AIM2在多种肿瘤中有异常表达,在结直肠癌、肝癌中表现为抑癌效应,在皮肤鳞状细胞癌中却表现出促癌效应,沉默AIM2可减轻癌症患者放化疗的胃肠道反应。AIM2多重角色及其作用机制的研究赋予肿瘤免疫治疗学更多的视角与方向。As a cytosolic innate immune receptor,AIM2 can recognize double-strand DNA(dsDNA)released during pathogenic assault.Upon binding to DNA,AIM2 assembles a multiprotein complex termed the inflammasome,which drives pyroptosis and secretion of inflammatory cytokines.Aberrant expression of AIM2 has been reported in a range of tumor tissues,suggesting that it may have unique roles in different types of cancer.Some researches show that AIM2 is beneficial in the hepatocellular carcinoma(HCC)and colorectal cancer(CRC),but detrimental in the cutaneous squamous cell carcinoma(cSCC).Therapeutic inhibition of AIM2 may benefit to gastrointestinal syndrome and hematopoietic failure caused by ionizing radiation and chemotherapeutic agents.In this review,the recent progress on the role of the AIM2 in cancer will be highlighted.These novel functions of AIM2 provides new insights into the immune-targeted cancer therapies.

关 键 词：AIM2 肿瘤 DNA感受器 

分 类 号：R34[医药卫生—基础医学]