比率型电化学传感器构建策略的研究进展  

Research progress on construction strategy of ratiometric electrochemical sensors

作　　者：杜敏 郑雅妮 戴乐天 周学敏[2] 洪俊丽[2] 杨杰[1] DU Min;ZHENG Yani;DAI Letian;ZHOU Xuemin;HONG Junli;YANG Jie(State Key Laboratory of Natural Medicines,China Pharmaceutical University,Nanjing 211100,China;School of Pharmacy,Nanjing Medical University,Nanjing 211166,China;School of Pharmaceutical Sciences,Shandong University,Jinan 250012,China)

机构地区：[1]中国药科大学天然药物活性组分与药效国家重点实验室,江苏南京211100 [2]南京医科大学药学院,江苏南京211166 [3]山东大学药学院,山东济南250012

出　　处：《药学研究》2021年第8期528-536,共9页Journal of Pharmaceutical Research

基　　金：国家自然科学基金面上项目(No.81773681、81773986);江苏省卫生健康委科研项目(No.Z2020009);云南省烟草化学重点实验室开放课题(No.2020539200340206);江苏省高等学校大学生创新创业训练计划重点项目(No.201810312032Z)。

摘　　要：电化学传感在生物分析和药品检测等领域应用广泛,然而,传统电化学传感常为单信号输出,易受内外因素的影响。近年来,比率型电化学传感器研究取得显著进展,其双信号输出特性为分析提供内置校正因子,消除干扰,显著提高了检测的重现性、准确度和灵敏度。比率型电化学传感器显著拓展了其在医药分析、疾病诊断、环境监控等领域的应用。本文综述了比率型电化学传感器构建策略的研究进展,并展望了其未来发展趋势。The electrochemical sensors have been widely applied in the fields of biological analysis and drug inspection due to a series of advantages.However,conventional electrochemical sensors are often single-signal output,which is easily affected by internal and external factors.Recently,the application of ratiometric electrochemical sensors has shown initial potential.The dual-signal output characteristics of ratiometric electrochemical sensors can provide built-in correction factors for analysis,thereby overcoming interference and significantly improving the reproducibility,accuracy and sensitivity of detection.The ratiometric electrochemical sensors have significantly expanded the application in medical analysis,disease diagnosis,environmental monitoring and other fields.This review mainly reports the research progress of ratiometric electrochemical sensors construction strategy,and prospects its future development.

关 键 词：比率型 电化学传感器 双信号 构建策略 电化学检测 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置]