苦参碱和氧化苦参碱对预防口腔疾病的临床药理作用研究进展  

Research Progress on Clinical Pharmacologic Effects of Matrine and Oxymatrine in Prevention and Treatmet for Stomatopathy

作　　者：张明发[1] 沈雅琴[1] ZHANG Ming-fa;SHEN Ya-qin(Shanghai Meiyou Pharmaceutical Co.,Ltd,Shanghai 201204,China)

机构地区：[1]上海美优制药有限公司,上海201204

出　　处：《抗感染药学》2021年第6期781-784,共4页Anti-infection Pharmacy

摘　　要：氧化苦参碱能保护牙周膜细胞免遭内毒素伤害,能抑制牙周炎症和牙槽骨吸收,还能治疗化学性烧灼引起的兔口腔溃疡和流行性腮腺炎,也能阻滞白假丝酵母黏附于人口腔黏膜上皮细胞。这些作用均与苦参碱和氧化苦参碱具有广谱的抗菌、抗病毒、抗炎和免疫调节作用有关。苦参碱和氧化苦参碱还具有抗头颈部肿瘤的作用。临床上已将复方苦参注射液(苦参碱和氧化苦参碱为其主要有效成分)用于防治头颈部肿瘤放疗时引起的放射性黏膜炎。文中综述苦参碱和氧化苦参碱对预防口腔疾病的临床药理作用的文献,并对其研究进展做了分析。Oxymatrine can protect periodontal ligament cells from injury of lipopolysaccharide,and inhibit periodontal inflammation and alveolar resorption.Matrine can treat oral ulcers in rabbits induced by chemical burning and epidemic parotitis,and prevent adhesion of Candida albicans to human oral mucosal epithelial cells.All of these are related to broad-spectrum anti-bacteria,anti-virus,anti-inflammation,and immunoregulation of matrine and oxymatrine.Matrine and oxymatrine have the effects against cephalocervical tumors.The compound Kushen injection,composed of matrine and oxymatrine,has been used to prevent and treat the radiate stomatitis caused by radiotherapy for head and neck tumors in clinic.In this paper,the literatures on the clinical pharmacological effects of matrine and oxymatrine in prevention of oral diseases are reviewed,and the research progress of matrine is analyzed.

关 键 词：苦参碱 氧化苦参碱 口腔疾病 口腔黏膜炎 牙周炎 

分 类 号：R961[医药卫生—药理学]