甲状腺髓样癌术后复发处理原则  

Principles of management for postoperative recurrence of medullary thyroid carcinoma

作　　者：王宇 渠宁 魏文俊 嵇庆海 WANG Yu;QU Ning;WEI Wen-jun(Department of Head and Neck Surgery,Fudan University Shanghai Cancer Center,Shanghai 200032,China)

机构地区：[1]复旦大学附属肿瘤医院头颈外科复旦大学上海医学院肿瘤学系,上海200032

出　　处：《中国实用外科杂志》2021年第8期874-877,共4页Chinese Journal of Practical Surgery

基　　金：国家自然科学基金面上项目(No.82072951);上海市科学技术委员会项目(No.19411966600);上海市申康医院发展中心项目(No.SHDC2020CR6003)。

摘　　要：甲状腺髓样癌(MTC)具有初治后易局部复发、区域淋巴结侵犯和肺、骨等远处转移的倾向,预后相对较差。国内临床实践中,对于该类病人术后随访评估方案及处理原则等问题仍然存在争议与分歧。结合国内外指南共识及笔者中心相关研究结果,建议局部复发且有明确病灶者以手术治疗为主,而无法手术或远处转移的病人则强调围绕基因靶点的个体化全身治疗。Medullary thyroid carcinoma(MTC) has a tendency to develop local recurrence,regional lymph node invasion,and distant metastasis to lungs and bones after initial treatment,and the prognosis is relatively poor.There are still controversies and divergences on some issues in clinical practice,such as postoperative follow-up evaluation plans and therapeutic principles for recurrent patients.The principles of management for recurrent MTC based on the consensus of domestic and foreign guidelines,and the relevant research results of author’s center,surgical treatment is the main treatment for patients with local recurrence of clear lesions,while the individualized systemic treatment on gene targets is recommended to patients with unresectable lesions or distant metastasis.

关 键 词：甲状腺髓样癌 术后复发 治疗原则 

分 类 号：R6[医药卫生—外科学]