甲钴胺联合α-硫辛酸治疗糖尿病周围神经病变的效果及安全性分析  

Effectiveness and Safety Analysis of Mecobalamin Combined with α-lipoic Acid in the Treatment of Diabetic Peripheral Neuropathy

作　　者：殷宏宇 王晓虹[1] 姜家奇 梁杨 郭欣 郑晓君[1] YIN Hongyu;WANG Xiaohong;JIANG Jiaqi;LIANG Yang;GUO Xin;ZHENG Xiaojun(Department of Neuroelectrophysiology,Dalian Municipal Central Hospital,Dalian 116033,Liaoning Province,China)

机构地区：[1]大连市中心医院神经电生理科,辽宁大连116033

出　　处：《中国实用乡村医生杂志》2021年第8期61-63,67,共4页Chinese Practical Journal of Rural Doctor

摘　　要：目的分析甲钴胺联合α-硫辛酸治疗糖尿病周围神经病变的效果及安全性。方法选取2019年2月-2020年9月在大连市中心医院治疗的130例糖尿病周围神经病变患者,以随机数表法分成观察组及对照组各65例,两组均予以降糖、控制饮食及运动锻炼等干预,同时,对照组实施甲钴胺治疗,观察组实施甲钴胺联合α-硫辛酸治疗,对比两组疗效、安全性,以及治疗前后神经电生理指标。结果观察组总有效率98.46%,高于对照组的86.15%,差异有统计学意义(P<0.05)。治疗后两组正中神经及腓总神经运动/感觉神经的有关传导速度均较治疗前更高,且观察组较对照组更高,差异均有统计学意义(P<0.05)。观察组不良反应总发生率为6.15%,高于对照组的4.62%,但差异无统计学意义(P>0.05)。结论甲钴胺联合α-硫辛酸治疗糖尿病周围神经病变,较只应用甲钴胺的疗效更好,能够有效改善患者的神经电生理指标,同时,具有较好的安全性,值得推广。Objective To study the function of neuroelectrophysiological parameters(NLPP)and safety analysis of mecobalamin combined withα-lipoic acid in the treatment of diabetic peripheral neuropathy(DPN).Methods A total of 130 cases of DPN patients,which were treated in Dalian Municipal Central Hospital from February 2019 to September 2020,were divided into observation and control group using random number table method(65 cases in each group).Both groups were given hypoglycemic,diet control and exercise intervention.The control group was given mecobalamin treatment,and the observation group was given mecobalamin combined with a-lipoic acid.The effectiveness,safety,and neurophysiological parameters before and after treatment were compared between two groups.Results Total effective rate of observation group was 98.46%,which was significantly higher than 86.15%of control group(P<0.05).The motor/sensory nerve conduction velocities of median and peroneal nerves after treatment in two groups were significantly higher than before treatment,meanwhile,the observation group was significantly higher than control group(P<0.05).Compared with 4.62%of control group,total incidence of adverse reactions in observation group was 6.15%(P>0.05).Conclusion Mecobalamin combined withα-lipoic acid is more effective in treatment of DPN patients than single mecobalamin treatment,which can effectively improve the levels of NLPP,and has high safety.It's worth promoting.

关 键 词：糖尿病周围神经病变 甲钴胺 Α-硫辛酸 神经电生理指标 效果 安全性 

分 类 号：R58[医药卫生—内分泌]