针刺联合培元化痰汤治疗肥胖型多囊卵巢综合征脾虚痰湿型的临床疗效及对性激素的影响  

Clinical efficacy of acupuncture combined with Peiyuan Huatan Decoction for obese polycystic ovary syndrome of spleen-deficient phlegm-dampness type and its effect on sex hormone

作　　者：杜晓娜 孙莎莎 管圆 王成喜[1] 孟欣 DU Xiaona;SUN Shasha;GUAN Yuan;WANG Chengxi;MENG Xin(Department of Traditional Chinese Medicine,The Eighth People's Hospital of Qingdao,Qingdao,Shandong 266000;不详)

机构地区：[1]山东省青岛市第八人民医院中医科,山东青岛266000 [2]山东省青岛市第八人民医院消化科,山东青岛266000 [3]山东省青岛疗养院中医科

出　　处：《河北中医》2021年第4期643-647,共5页Hebei Journal of Traditional Chinese Medicine

基　　金：山东省青岛市卫生健康委员会2020年度中医药科研计划项目(编号:2020-zyy033);山东省青岛市卫生健康委员会2020年青岛市医疗卫生优秀人才培养项目(青卫科教字〔2019〕9号)。

摘　　要：目的观察针刺联合培元化痰汤治疗肥胖型多囊卵巢综合征脾虚痰湿型的临床疗效及对性激素的影响。方法将96例肥胖型PCOS患者按照随机数字表法分为2组,治疗组48例予针刺联合培元化痰汤治疗,对照组48例予盐酸二甲双胍片治疗,2组均治疗3个月,治疗后随访3个月。比较2组疗效;比较2组治疗前后体质量指数(BMI)、胰岛素抵抗指数(HOMA-IR)、窦卵泡计数(AFC)及血清黄体生成激素(LH)、卵泡刺激素(FSH)、睾酮(T)、LH/FSH变化。结果治疗组总有效率95.83%(46/48),对照组总有效率66.67%(32/48),治疗组疗效优于对照组(P<0.05)。2组治疗后BMI、HOMA-IR均较本组治疗前降低(P<0.05),且治疗组降低更明显(P<0.05)。2组治疗后AFC均较本组治疗前减少(P<0.05),且治疗组减少更明显(P<0.05)。2组治疗后LH、LH/FSH、T均较本组治疗前降低(P<0.05),且治疗组降低更明显(P<0.05)。结论针刺联合培元化痰汤治疗肥胖型PCOS,可显著降低患者体质量,改善胰岛素抵抗(IR),降低AFC及性激素LH、LH/FSH、T水平。Objective To observe the clinical efficacy of acupuncture combined with Peiyuan Huatan Decoction for obese polycystic ovary syndrome(PCOS)of spleen-deficient phlegm-dampness type and its effect on sex hormone.MethodsNinety-six patients with obese PCOS were randomly divided into two groups,48 cases in treatment group were treated with acupuncture combined with Peiyuan Huatan Decoction,and 48 cases in control group were treated with metformin hydrochloride tablets.Both groups were treated for 3 months,and follow-up for 3 months after treatment.Curative effect,body mass index(BMI),Insulin resistance index(HOMA-IR),antral follicle count(AFC),luteinizing hormone(LH),follicle stimulating hormone(FSH),testosterone(T),as well as luteinizing hormone(LH)and follicle-stimulating hormone(FSH)between groups were compared before and after treatment.ResultsThe total effective rates were significantly better in treatment group than in control group[95.83%(46/48)vs 66.67%(32/48),(P<0.05),respectively].Compared with before treatment,BMI,HOMA-IR,AFC,LH,LH/FSH and T in groups were lower after treatment(P<0.05),which in treatment group were significantly decreased(P<0.05).ConclusionFor patients with obese PCOS,acupuncture combined with Peiyuan Huatan Decoction can significantly reduce body weight,improve insulin resistance(IR),and reduce levels of AFC and sex hormones of LH,LH/FSH,T.

关 键 词：多囊卵巢综合征 脂代谢障碍 针刺疗法 中药疗法 

分 类 号：R271.9[医药卫生—中西医结合]