急性降主动脉夹层病情发生发展影响因素分析  

ANALYSIS OF FACTORS INFLUENCING OCCURRENCE AND DEVELOPMENT OF ACUTE DESCENDING AORTIC DISSECTION

作　　者：张臻 赵振华 韩继彪 刘磊 朱军辉 王消防 孟庆友[2] ZHANG Zhen;ZHAO Zhenhua;HAN Jibiao;LIU Lei;ZHU Junhui;WANG Xiaofang;MENG Qingyou(Department of Cardiovascular Surgery,Fuyang People's Hospital,Fuyang 236000,China)

机构地区：[1]安徽省阜阳市人民医院心外科,236000 [2]苏州大学附属第一医院心脏大血管外科

出　　处：《中国煤炭工业医学杂志》2021年第4期404-408,共5页Chinese Journal of Coal Industry Medicine

基　　金：国家自然科学基金资助项目(编号:81970397)。

摘　　要：目的探究急性降主动脉夹层病情发生与发展的影响因素。方法选取2013年11月—2018年11月该院收治的急性降主动脉夹层患者40例为观察组,并同时选取40例健康体检个体为对照组,分析观察组所有患者临床资料,并将对照组相应指标与观察组进行单因素对比,将差异显著项进行Logistic回归分析,探究急性降主动脉发病影响因素;后观察组患者设为A组,2个月后入院随访检查设为B组,同样将检查结果做单因素对比分析,并将差异显著项进行Logistic回归分析,探究急性降主动脉病情发展影响因素。结果观察组和对照组基线资料单因素比较显示,观察组平均动脉压、D-二聚体以及血肌酣水平明显高于对照组,差异有统计学意义(P<0.05),其余项目二组比较差异无统计学意义(P>0.05);A组与B组基线资料比较显示,B组平均动脉压、D-二聚体水平、血肌酣水平、凝血酶原时间明显高于A组,心脏射血分数明显低于A组,差异有统计学意义(P<0.05),其余项目差异无统计学意义(P>0.05);根据观察组和对照组基线资料中单因素比较,纳入平均动脉压、D-二聚体以及血肌酐作自变量,进行Logistic回归分析,分析结果显示,平均动脉压与患者急性降主动脉夹层发生呈正相关(P=0.008,OR=1.480,95%CI=0.505~2.205),血肌酐与患者急性降主动脉夹层发生呈正相关(P=0.013,OR=1.626,95%CI=1.108~3.091),D-二聚体与患者急性降主动脉夹层发生未表现出相关性(P>0.05);根据A组和B组基线资料中单因素比较,纳入平均动脉压、D-二聚体、血肌酐以及凝血酶原时间作自变量,进行Logistic回归分析,分析结果显示,平均动脉压与患者急性降主动脉夹层发展呈正相关(P=0.035,OR=1.265,95%CI=1.017~1.574),血肌酐与患者急性降主动脉夹层发展呈正相关(P=0.011,OR=1.521,95%CI=1.101~2.101),凝血酶原时间与患者急性降主动脉夹层发展呈正相关(P=0.002,OR=12.468,95%CI=2.569~60.511),D-二聚�Objective To explore the influencing factors of the occurrence and development of acute descending aortic dissection.Methods In November 2013 to November 2018,forty patients with acute descending aorta dissection of Fuyang People’s Hospital for observation group,and at the same time to choose 40 cases of healthy check-up individuals as control group,all patients clinical data analysis group,index and the observation group and control group in corresponding single factor comparison,will be significant difference Logistic regression analysis,to explore the acute descending aorta morbidity factors.Patients in the post-observation group were assigned to group A,and patients in the follow-up examination 2 months later were assigned to group B.Univariate comparative analysis was also performed on the examination results,and Logistic regression analysis was performed on the significantly different items to explore the influencing factors of the disease development of acute descending aorta.Results The single-factor comparison of baseline data between the observation group and the control group showed that the mean arterial pressure,d-dimer and hemomyosin levels in the observation group were significantly higher than those in the control group,with statistically significant difference(P<0.05),while the other two groups had no significant difference(P>0.05).The baseline data of group A and group B showed that the average arterial pressure,d-dimer level,hemomyositis level and prothrombin time in group B were significantly higher than that in group A,and the cardiac ejection fraction was significantly lower than that in group A,with statistically significant differences(P<0.05),and no significant differences in other items(P>0.05).According to the univariate comparison between baseline data of the observation group and the control group,mean arterial pressure,d-dimer and serum creatinine were included as independent variables for Logistic regression analysis.The analysis results showed that:Mean arterial pressure was posi

关 键 词：急性降主动脉夹层 危险因素 影响因素 

分 类 号：R543.1[医药卫生—心血管疾病]