重组牛碱性成纤维细胞生长因子联合阿昔洛韦对手足口病患儿口腔溃疡及炎症因子水平的影响  

Effects of Recombinant Bovine Basic Fibroblast Growth Factor Combined with Acyclovir on Oral Ulcers and Levels of Inflammatory Factors in Children with Hand Foot Mouth Disease

作　　者：黄啸林[1] 罗彦妮 HUANG Xiaolin;LUO Yanni(The Affiliated Stomatological Hospital of Jiujiang University,Jiujiang Jiangxi 332000,China)

机构地区：[1]九江学院附属口腔医院,江西九江332000

出　　处：《药品评价》2021年第14期873-875,共3页Drug Evaluation

摘　　要：目的:探讨重组牛碱性成纤维细胞生长因子(rh-bFGF)联合阿昔洛韦在手足口病(HFMD)患儿中的疗效。方法:选取2019年7月至2020年1月于九江学院附属口腔医院收治的68例HFMD患儿,按随机数字表法分为对照组(34例)和观察组(34例)。对照组使用阿昔洛韦,观察组加用rh-bFGF,持续用药7 d。对比两组临床疗效、炎症因子水平、症状消退时间、不良反应。结果:观察组治疗总有效率91.18%较对照组70.59%高,差异有统计学意义(P<0.05);两组治疗前白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)比较,差异无统计学意义(P>0.05);观察组治疗7 d后的IL-6、TNF-α、IL-10较对照组低,差异有统计学意义(P<0.05);观察组口腔溃疡愈合时间、疱疹消退时间、发热消退时间较对照组短,差异有统计学意义(P<0.05);两组不良反应相当,差异无统计学意义(P>0.05)。结论:Rh-bFGF联合阿昔洛韦在HFMD患儿中效果确切,能够阻滞炎症因子分泌,加快症状消退,安全可行。Objective:To investigate the efficacy of recombinant bovine basic fibroblast growth factor(rh-bFGF)combined with acyclovir in children with hand-foot-mouth disease(HFMD).Methods:A total of 68 children with HFMD admitted to The Affiliated Stomatological Hospital of Jiujiang University from July 2019 to January 2020 were selected and divided into a control group(34 cases)and an observation group(34 cases)according to the random number table method.Acyclovir was used in the control group and rh-bFGF was added to the observation group for 7 days.The clinical efficacy,levels of inflammatory factors,time for symptom resolution,and adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 91.18%higher than that in the control group 70.59%,and there was a statistical difference(P<0.05);there was no statistical difference between the interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and interleukin-10(IL-10)of the two groups before treatment(P>0.05);IL-6,TNF-α,IL-10 in the observation group were lower than those in the control group after 7 days of treatment,and there was a statistical difference(P<0.05);the observation group had a shorter time for oral ulcers,herpes,and fever to subside than the control group,with statistical differences(P<0.05);the two groups had similar adverse reactions,and there was no statistical difference(P>0.05).Conclusion:Rh-bFGFcombined with acyclovir has a definite effect in children with HFMD.It can block the secretion of inflammatory factors,accelerate the resolution of symptoms,and is safe and feasible.

关 键 词：手足口病 重组牛碱性成纤维细胞生长因子 阿昔洛韦 炎症因子 口腔溃疡 

分 类 号：R725.1[医药卫生—儿科]