贵州省黔东南州侗族人群尿砷及相关因素与高血压患病率的关联性探究  

Aassociation between urinary arsenic and related factors and prevalence of hypertension among Dong minority of Qiandongnan Prefecture,Guizhou Province

作　　者：金照凤 尹朝晖 雷娟[3] 唐学杰 刘雅兰 张才良 杨倩媛 张林源 洪峰 JIN Zhao-feng;YIN Zhao-hui;LEI Juan;TANG Xue-jie;LIU Ya-lan;ZHANG Cai-liang;YANG Qian-yuan(School of Public Health,Guizhou Medical University,Key Laboratory of Environmental Pollution and Disease Surveillance,Guiyang,Guizhou 550025,China;不详)

机构地区：[1]贵州医科大学公共卫生学院,环境污染与疾病监控教育部重点实验室,贵州贵阳550025 [2]贵州医科大学第二附属医院,贵州凯里556000 [3]贵阳市疾病预防控制中心,贵州贵阳550003 [4]贵州医科大学大学城医院,贵州贵阳550025

出　　处：《现代预防医学》2021年第16期2881-2886,共6页Modern Preventive Medicine

基　　金：国家重点研发计划课题(2017YFC0907301);贵州省苗族、侗族、布依族世居自然人群环境暴露与健康风险的前瞻性队列研究(黔科合平台人才[2018]5403)。

摘　　要：目的探讨贵州黔东南州侗族尿砷浓度及高血压相关因素与高血压患病率的关联性。方法通过分层多阶段抽样方法调查贵州省黔东南州30~79岁侗族居民4580名,采用问卷调查、体格检查采集居民相关的健康状况资料,并收集尿样。使用电感耦合等离子体质谱检测尿砷浓度,采用非条件logistic回归进行分析。结果黔东南州侗族高血压患病率为31.5%,女性(OR=0.539,95%CI:0.445~0.653)、BMI<18.5kg/m^(2)(OR=0.624,95%CI:0.438~0.890)为高血压的保护因素(P<0.05);年龄(OR=2.670,95%CI:1.887~3.778;OR=5.506,95%CI:3.922~7.729;OR=9.347,95%CI:6.577~13.283;OR=14.397,95%CI:9.632~21.520),饮酒(OR=1.335,95%CI:1.070~1.666)、腹部肥胖(OR=1.700,95%CI:1.397~2.069)、超重(OR=1.626,95%CI:1.338~1.976)和肥胖(OR=2.888,95%CI:2.222~3.752)是高血压的危险因素(P<0.05);尿砷高浓度组与高血压患病率之间存在负相关,OR=0.763,95%CI=0.625~0.930,全部调查对象及非高血压患者尿砷浓度与收缩压均存在负相关关系(P<0.05),β值和95%CI分别为:-1.967(-3.531~-0.427)、-0.036(-2.415~-0.137)。结论黔东南州侗族高血压患病率较高,主要危险因素包括年龄、饮酒、腹部肥胖、BMI较大;黔东南州侗族高血压患病率、收缩压都与尿砷浓度之间呈负相关关系。Objective To explore the relationship between urinary arsenic concentration and hypertension-related factors of the Dong minority in Qiandongnan Prefecture of Guizhou Province and the prevalence of hypertension.Methods A stratified multi-stage sampling method was used to investigate 4580 Dong Minority aged 30-79 years old in Qiandongnan Prefecture,Guizhou Province.Questionnaire surveys and physical examinations were used to collect relevant health data and urine sam-ples.Inductively coupled plasma mass spectrometry was applied to detect the urine arsenic concentration,and unconditional logistic regression analysis was performed.Results The prevalence of hypertension in the Dong minority in Qiandongnan Prefecture was 31.5%,and female(OR=0.539,95%CI:0.445-0.653)and BMI<18.5 kg/m^(2)(OR=0.624,95%CI:0.438-0.890)were protective factors for hypertension(P<0.05);age(OR=2.670,95%CI:1.887-3.778;OR=5.506,95%CI:3.922-7.729;OR=9.347,95%CI:6.577-13.283;OR=14.397,95%CI:9.632-21.520),drinking(OR=1.335,95%CI:1.070-1.666),abdominal obesity(OR=1.700,95%CI:1.397-2.069),overweight(OR=1.626,95%CI:1.338-1.976)and obesity(OR=2.888,95%CI:2.222-3.752)were risk factors for hypertension(P<0.05).There was a negative correlation between the high concentration of urinary arsenic and the risk of hypertension(OR=0.763,95%CI=0.625-0.930).There was a negative correlation between urinary arsenic concentration and systolic blood pressure in all investigated subjects and non-hypertensive patients(P<0.05),withβvalues and 95%CI:-1.967(-3.531 to-0.427)and-0.036(-2.415 to-0.137),respectively.Conclusion The prevalence of hypertension is high among Dong people in Qiandongnan,and the main risk factors include age,alcohol consumption,abdominal obesity,and larger BMI.There is a negative correlation between the prevalence of hypertension,systolic blood pressure,and urinary arsenic concentration among Dong people in Qiandongnan.

关 键 词：侗族 尿砷 高血压 关联性分析 

分 类 号：R544.1[医药卫生—心血管疾病]