慢性腹泻与原发性免疫缺陷病  

Chronic diarrhea and primary immunodeficiency

作　　者：何庭艳[1] 杨军[1] HE Ting-yan;YANG Jun(Department of Rheumatology and Immu­nology,Shenzhen,Children,s Hospital,Shenzhen 518038,China)

机构地区：[1]深圳市儿童医院风湿免疫科,广东深圳518038

出　　处：《中国实用儿科杂志》2021年第7期497-502,共6页Chinese Journal of Practical Pediatrics

基　　金：深圳市三名工程(SZSM201812002);深圳市医学重点学科建设经费资助(SZGSP012)。

摘　　要：慢性腹泻是儿科常见的胃肠道症状,而胃肠道是人体最大的免疫器官,储存淋巴细胞最多。多种原发性免疫缺陷病将出现胃肠道表现,包括顽固性腹泻、吸收不良、炎症性肠病/类炎症性肠病或生长迟滞等。文章将阐述原发性免疫缺陷病相关慢性腹泻的病因、线索提示、临床特征及处理措施。Chronic diarrhea is a common gastrointestinal symptom in pediatrics.The gastrointestinal tract is the biggest organ of the immune system,with the largest reservoir of lymphocytes in the human body.A variety of primary immunodeficiency diseases present with gastrointestinal manifestations,including refractory diarrhea,malabsorption,inflammatory bowel disease(IBD)/IBD-like,or failure to thrive.This article will describe the etiology,clinical clues,clinical features and management of chronic diarrhea associated with primary immunodeficiency disease.

关 键 词：慢性腹泻 原发性免疫缺陷病 联合免疫缺陷病 慢性肉芽肿 湿疹血小板减少伴免疫缺陷综合征 

分 类 号：R72[医药卫生—儿科]