左西孟旦在急性心肌梗死伴心力衰竭患者治疗中的应用效果  

Application Effect of Leosimendan in Treatment of Acute Myocardial Infarction with Heart Failure

作　　者：曹一波 CAO Yibo(Department of Cardiovascular Internal Medicine,Fuxin Mine General Hospital,Liaoning Health Industry Group,Fuxin 123000,China)

机构地区：[1]辽宁省健康产业集团阜新矿总医院心血管内科,辽宁阜新123000

出　　处：《中国医药指南》2021年第24期67-68,共2页Guide of China Medicine

摘　　要：目的探究急性心肌梗死伴心力衰竭患者在治疗过程中应用左西孟旦的临床效果。方法于2017年4月至2018年11月随机选取本院心内科收治的86例急性心肌梗死伴心力衰竭患者,并按照双盲法分为两组,对照组43例患者采用多巴酚丁胺治疗,试验组43例患者采用左西孟旦治疗,对两组患者的治疗效果、左室射血分数与脑钠肽水平的变化进行对比。结果试验组患者治疗总有效率为95.35%,明显比对组患者的81.40%高(P<0.05);治疗前,两组患者左室射血分数与脑钠肽水平比较,差异无统计学意义(P>0.05);治疗后,两组患者左室射血分数明显高于治疗前,脑钠肽水平明显低于治疗前,且试验组患者左室射血分数与脑钠肽水平升高或降低程度大于对照组(P<0.05)。结论急性心肌梗死伴心力衰竭患者在治疗过程中应用左西孟旦,可使患者的左室射血分数明显升高,使脑钠肽水平有效升高,对患者治疗效果的提高也有积极的影响。Objective To explore the clinical effect of leosimendan in the treatment of patients with acute myocardial infarction complicated with heart failure.Methods From April 2017 to November 2018,86 patients with acute myocardial infarction complicated with heart failure admitted to the Department of Cardiology of our hospital were randomly selected and divided into two groups according to double-blind method,43 patients in the control group were treated with dobutamine while 43 patients in the experimental group were treated with leosimendan.The total effective rate of treatment,the changes of left ventricular ejection fraction and brain natriuretic peptide level in the two groups were compared.Results The total effective rate of the experimental group was 95.35%,significantly higher than 81.40%of the group(P<0.05).The comparison of left ventricular ejection fraction and brain natriuretic peptide level between the two groups before treatment showed no significant difference(P>0.05).After treatment,the left ventricular ejection fraction of the two groups of patients was significantly higher than that before treatment,and the level of brain natriuretic peptide was significantly lower than that before treatment,and the degree of increase or decrease of left ventricular ejection fraction and brain natriuretic peptide level in the experimental group was greater than that in the control group(P<0.05).Conclusion The application of leosimendan in the treatment of patients with acute myocardial infarction complicated with heart failure can significantly increase the left ventricular ejection fraction of patients,effectively increase the level of brain natriuretic peptide,and also have a positive impact on the improvement of the treatment effect of patients.

关 键 词：急性心肌梗死 心力衰竭 左西孟旦 

分 类 号：R542.22[医药卫生—心血管疾病]