转运体介导药物相互作用的研究现状及展望  

Research status and prospect of transporter-mediated drug-drug interactions

作　　者：孟强[1] 刘克辛[1] MENG Qiang;LIU Kexin(College of Pharmacy,Dalian Medical University,Dalian 116044,Liaoning,China)

机构地区：[1]大连医科大学药学院,辽宁大连116044

出　　处：《中国临床药理学与治疗学》2021年第8期876-888,共13页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金面上项目(81874324,81302826)。

摘　　要：临床上,多种药物联合应用于疾病治疗现象极为常见,然而,合并用药易导致药物相互作用(drug-drug interaction,DDI)的发生,进而引起药物疗效的降低或丧失,导致不良反应的增加,甚至会引发药物严重不良反应。药物转运体通过影响合用药物在体内的处置过程,在DDI的发生发展中发挥至关重要的作用。本文概述了DDI与转运体的关系,着重对转运体介导的DDI对药物体内过程的影响及其与疾病和多药耐药的关系作一综述,并简要介绍了我国现行的药物相互作用研究的指导原则,旨在提醒临床医务工作者重视转运体介导的DDI,提高联合用药的安全性,并为疾病治疗和避免多药耐药提供新的视野和思路。In clinic,it is very common that a variety of drugs are used in the treatment of diseases.However,the combination of drugs can easily lead to the occurrence of drug-drug interaction(DDI),which can lead to the reduction or loss of drug efficacy,the increase of adverse reactions,and even lead to serious adverse reactions.Drug transporters play an important role in the occurrence and development of DDI by influencing the disposal process of combined drugs in vivo.In this paper,the relationship between DDI and transporter was summarized.The effects of transporter-mediated DDI on the drug disposal process in vivo,and the relations of DDI and disease or multidrug resistance were reviewed.The current guiding principles of DDI research in China were briefly introduced.The purpose was to remind clinical medical workers to pay attention to transporter-mediated DDI and improve the safety of drug combination,further to provide a new vision and ideas for disease treatment and avoiding multidrug resistance.

关 键 词：转运体 药物相互作用 疾病 多药耐药 

分 类 号：R969.2[医药卫生—药理学]