我国代谢调控与药物靶标发现研究的进展与展望  

Metabolic regulation and drug target discovery researches in China:Progress and prospect

作　　者：郝海平[1] HAO Haiping(School of Pharmacy,China Pharmaceutical University,Nangjing210009,Jiangsu,China)

机构地区：[1]中国药科大学药学院,江苏南京210009

出　　处：《中国临床药理学与治疗学》2021年第8期955-963,共9页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金重点项目(81930109)。

摘　　要：代谢调节是生物体适应内外环境变化的重要机制。代谢性小分子作为功能多样的信使广泛参与到信号传递网络与器官对话,对于理解生理过程、揭示疾病机制、发现药物靶标具有重要意义。本文对近年来我国学者在代谢调控与药物靶标发现领域取得的主要进展进行分析,展望其发展方向,为基于代谢调控的新药研究提供参考。Metabolic regulation is an important mechanism by which organisms adapt to changes in the internal and external environment.Metabolic small molecules function as versatile messengers involved in signaling networks and organ crosstalk,which carries great implications for understanding physiological processes,revealing disease mechanisms and discovering drug targets.In this review,we present an overview of the main progresses in metabolic regulation and drug target discovery researches in China,and look forward to its future direction,which may provide a reference for the drug development endeavor based on metabolic regulation.

关 键 词：代谢调控 靶标发现 研究进展 新药研发 

分 类 号：R969.2[医药卫生—药理学]