二至丸合知柏地黄丸联合常规疗法治疗肾病综合征肝肾阴虚证临床研究  

Clinical Study on Erzhi Pills and Zhibai Dihuang Pills Combined with Routine Therapy for Nephrotic Syndrome with Liver-Kidney Yin Deficiency Syndrome

作　　者：翁秀平 WENG Xiuping(Department of Nephrology,Pinghu first people's Hospital,Pinghu 314200,Zhejiang)

机构地区：[1]平湖市第一人民医院肾内科,浙江平湖314200

出　　处：《新中医》2021年第16期16-20,共5页New Chinese Medicine

摘　　要：目的:观察二至丸合知柏地黄丸加减联合常规疗法治疗肾病综合征肝肾阴虚证的疗效以及对血清超敏C-反应蛋白(hs-CRP)和肿瘤坏死因子(TNF)-α水平的影响。方法:选择88例肾病综合征患者,按随机数字表法分为对照组及观察组各44例。2组均给予常规基础治疗措施,对照组给予醋酸泼尼松片治疗,观察组在对照组治疗基础上给予二至丸合知柏地黄丸治疗。2组均连续治疗6个月。比较2组治疗前后肾功能指标、肝肾阴虚证症状评分、血清hs-CRP和TNF-α水平变化以及治疗过程中不良反应情况,观察2组临床疗效。结果:治疗后,2组血清白蛋白指标值均较治疗前升高,24 h尿蛋白定量、血尿素氮、血肌酐指标值均较治疗前下降(P<0.01),观察组血清白蛋白指标值高于对照组(P<0.01),其余3项指标值均低于对照组(P<0.01)。2组浮肿、眩晕、口干、咽喉干痛、心烦急躁、腰酸症状评分均较治疗前下降(P<0.01),观察组6项症状评分均低于对照组(P<0.01)。治疗6个月后,观察组总有效率为93.18%,对照组为72.73%,2组比较,差异有统计学意义(P<0.05)。2组血清hs-CRP、TNF-α水平均较治疗前下降(P<0.01),观察组2项水平均低于对照组(P<0.01)。治疗过程中,观察组不良反应发生率为50%,对照组为75%,2组比较,差异有统计学意义(P<0.05)。结论:二至丸合知柏地黄丸加减联合常规疗法治疗肝肾阴虚型肾病综合征的疗效显著,能缓解机体炎症反应程度,减轻肾脏损伤,有效降低激素所引起的不良反应。Objective:To observe the curative effect of modified Erzhi pills and Zhibai Dihuang pills combined with routine therapy for nephrotic syndrome with liver-kidney yin deficiency syndrome and its effect on levels of high-sensitivity C-reactive protein(hs-CRP) and tumor necrosis factor(TNF)-α in serum. Methods: A total of 88 cases of patients with nephrotic syndrome were divided into the control group and the observation group according to the random number table method, 44 cases in each group. Both groups were given routine basic treatment measures;the control group was additionally treated with prednisone,and the observation group was additionally treated with Erzhi pills and Zhibai Dihuang pills based on the treatment of the control group. Both groups were treated for six months. The changes in kidney function indexes,symptom scores of liver-kidney yin deficiency syndrome and levels of hs-CRP and TNF-α in serum before and after treatment as well as the clinical effect and adverse reactions in the two groups were compared. The clinical effect was compared between the two group. Results:After treatment,the albumin in serum in the two groups were increased when compared with those before treatment,and twenty-four-hour urinary protein,blood urea nitrogen and serum creatinine were decreased(P<0.01);the albumin in serum in the observation group was higher than that in the control group(P<0.01),and the other three indexes were lower(P<0.01). After treatment,the symptom scores of edema,vertigo,xerostomia,dry throat pain,vexation and irritability,and sore waist in the two groups were decreased when compared with those before treatment(P<0.01),and the six symptom scores in the observation group were lower than those in the control group(P<0.01). After six-month treatment,the total effective rate was 93.18% in the observation group and 72.73% in the control group, the difference being significant(P<0.05). The levels of hs-CRP and TNF-α in serum in the two groups were decreased when compared with those before treatment(P<0

关 键 词：肾病综合征 肝肾阴虚证 二至丸 知柏地黄丸 

分 类 号：R277.5[医药卫生—中医学] R692