麝香通心滴丸联合尼可地尔针剂治疗急性心肌梗死PCI术后临床研究  

Clinical Study on Shexiang Tongxin Dropping Pills Combined with Nicorandil Injection for Acute Myocardial Infarction After PCI Surgery

作　　者：何志鹏 翁敏杰 唐延甜 吴琪 史佩剑 陈檀琦 章顺安 HE Zhipeng;WENG Minjie;TANG Yantian;WU Qi;SHI Peijian;CHEN Tanqi;ZHANG Shun'an(Department of Cardiology,Beilun District People's Hospital,Ningbo 315806,Zhejiang)

机构地区：[1]宁波市北仑区人民医院心血管内科,浙江宁波315806

出　　处：《新中医》2021年第16期46-49,共4页New Chinese Medicine

基　　金：浙江省中医药科技计划项目(2018ZB121)。

摘　　要：目的:观察麝香通心滴丸联合尼可地尔针剂对急性心肌梗死经皮冠状动脉介入术(PCI)术后患者血浆内皮素-1(ET-1)、超敏C-反应蛋白(hs-CRP)及心功能的影响。方法:选取急性心肌梗死PCI术后患者82例,按随机数字表法分为观察组和对照组各41例。2组患者均行PCI治疗,对照组术后给予尼可地尔针剂治疗,观察组在对照组基础上给予麝香通心滴丸治疗。比较2组临床疗效,检测治疗前后心肌酶、N末端脑钠肽前体(NT-proBNP)、ET-1、hs-CRP水平及心功能变化。结果:观察组总有效率为92.68%,高于对照组70.73%,差异有统计学意义(P<0.05)。治疗前,2组肌酸激酶同工酶(CK-MB)、肌钙蛋白T (cTnT)、NT-proBNP、ET-1及hs-CRP水平比较,差异无统计学意义(P>0.05)。治疗后,2组CK-MB、cTnT、NT-proBNP、ET-1及hs-CRP水平较治疗前降低(P<0.05),观察组CK-MB、cTnT、NT-proBNP、ET-1及hs-CRP水平低于对照组(P<0.05)。治疗前,2组左心室射血反射(LVEF)、左室舒张末期内径(LVEDD)比较,差异无统计学意义(P>0.05)。治疗后,2组LVEF较治疗前升高而LVEDD较治疗前降低(P<0.05),观察组LVEF高于对照组而LVEDD低于对照组(P<0.05)。结论:麝香通心滴丸联合尼可地尔针剂对急性心肌梗死PCI术后患者疗效良好,可降低血浆ET-1、hs-CRP及小肌酶水平,改善患者心功能。Objective: To observe the effect of Shexiang Tongxin dropping pills combined with nicorandil injection on plasma endothelin-1(ET-1),plasma high-sensitivity C-reactive protein(hs-CRP),and the heart function of patients with acute myocardial infarction after percutaneous coronary intervention(PCI). Methods:A total of 82 cases of patients with acute myocardial infarction after PCI surgery were selected and divided into the observation group and the control group according to the random number table method,41 cases in each group. Both groups were treated with PCI surgery. After surgery,the control group was given nicorandil injection,and the observation group was additionally given Shexiang Tongxin dropping pills based on the treatment of the control group. The clinical effect was compared between the two groups. The changes in levels of myocardial enzyme,N-terminal pro-B type natriuretic peptide(NT-proBNP),ET-1,and hs-CRP,as well as in the heart function were evaluated before and after treatment. Results:The total effective rate was 92.68% in the observation group,higher than that of 70.73% in the control group,the difference being significant(P<0.05). Before treatment,when compared levels of creatine kinase isoenzyme(CK-MB),cardiac troponin T(cTnT),NT-proBNP,ET-1,and hs-CRP between the two groups, there was no significance being found in the difference(P > 0.05). After treatment, levels of CK-MB, cTnT,NT-proBNP,ET-1,and hs-CRP in the two groups were decreased when compared with those before treatment(P<0.05),and the above levels in the observation group were lower than those in the control group(P<0.05). Before treatment,when compared left ventricle ejection fraction(LVEF) and left ventricular end-diastolic diameter(LVEDD) between the two groups,there was no significance being found in the difference(P>0.05). After treatment, LVEF levels in the two groups were increased when compared with those before treatment,and LVEDD levels were decreased(P<0.05). After treatment,LVEF level in the observation group was higher t

关 键 词：急性心肌梗死 经皮冠状动脉介入术 麝香通心滴丸 尼可地尔针剂 内皮素-1 超敏C-反应蛋白 N末端脑钠肽前体 心功能 

分 类 号：R542.22[医药卫生—心血管疾病]