针刺联合盐酸帕罗西汀片治疗轻中度抑郁症伴失眠临床研究  

Clinical Study on Acupuncture Combined with Paroxetine Hydrochloride Tablets for Mild and Moderate Depression Complicated with Insomnia

作　　者：谭孝琴 夏花 吴云 TAN Xiaoqin;XIA Hua;WU Yun(Liangzhu hospital,Yuhang District,Hangzhou,Zhejiang 311112;Lishui Second People's Hospital,Lishui,Zhejiang 323000)

机构地区：[1]杭州市余杭区良渚医院,浙江杭州311112 [2]丽水市第二人民医院,浙江丽水323000

出　　处：《新中医》2021年第16期139-142,共4页New Chinese Medicine

摘　　要：目的:观察针刺联合盐酸帕罗西汀片治疗轻中度抑郁症伴失眠的临床疗效。方法:选取100例轻中度抑郁症伴失眠患者,按随机数字表法分为研究组和对照组,每组50例。治疗期间,研究组剔除2例,对照组剔除1例。对照组给予盐酸帕罗西汀片治疗,研究组在对照组基础上加用针刺疗法治疗,2组均连续治疗6周。比较2组临床疗效及治疗前后抑郁程度、睡眠状况,记录2组不良反应。结果:研究组总有效率为97.92%,高于对照组的85.71%(P<0.05)。治疗后,研究组汉密尔顿抑郁量表17项(HAMD-17)、匹兹堡睡眠质量指数(PSQI)评分均低于对照组(P<0.05)。研究组躯体症状、头痛、头晕评分及Asberg抗抑郁药副反应量表(SERS)总分均低于对照组(P<0.05)。结论:针刺联合盐酸帕罗西汀片治疗轻中度抑郁症伴失眠,可以有效减轻患者的抑郁程度,改善其睡眠状况,且安全性较好。Objective:To observe the clinical effect of acupuncture combined with paroxetine hydrochloride tablets for mild and moderate depression complicated with insomnia. Methods:A total of 100 cases of patients with mild and moderate depression complicated with insomnia were divided into the study group and the control group according to the random number table method,50 cases in each group. The control group was treated with paroxetine hydrochloride tablets,and the study group was additionally treated with acupuncture based on the treatment of the control group. Both groups were treated for six weeks. The degree of depression and sleep status before and after treatment as well as the clinical effect in the two groups were compared, and the adverse reactions in the two groups were recorded. Results: The total effective rate was 97.92% in the study group,higher than that of 85.71% in the control group(P<0.05). After treatment,the scores of Hamilton Depression Rating Scale-17(HAMD-17) and Pittsburgh Sleep Quality Index(PSQI) in the study group were lower than those in the control group(P<0.05). The scores of physical symptoms,headache and dizziness and the total score of Side Effects Rating Scale(SERS) in the study group were lower than those in the control group(P<0.05). Conclusion:Acupuncture combined with paroxetine hydrochloride tablets for mild and moderate depression complicated with insomnia,which can effectively relieve the degree of depression and improve sleep status with good safety.

关 键 词：轻中度抑郁症 失眠 针刺 盐酸帕罗西汀片 汉密尔顿抑郁量表17项 匹兹堡睡眠质量指数 Asberg抗抑郁药副反应量表 

分 类 号：R246.6[医药卫生—针灸推拿学]