大黄苏打片联合西医综合治疗肝硬化门静脉高压症便秘患者的临床研究  

Clinical research of rhubarb compound tablets plus western medicine in cirrhotic portal hypertension patients with constipation

作　　者：崔晨 张莹 杨庆龙 CUI Chen;ZHANG Ying;YANG Qing-long(Department of Gastroenterology,Tongling Municipal Hospital,244000 Tongling,Anhui,China)

机构地区：[1]铜陵市立医院消化内科,安徽铜陵244000

出　　处：《临床消化病杂志》2021年第4期251-255,共5页Chinese Journal of Clinical Gastroenterology

基　　金：铜陵市卫计委科研课题项目(卫科研2016-24号)。

摘　　要：[目的]探讨大黄苏打片+西医综合治疗肝硬化门静脉高压症便秘的价值。[方法]选择112例肝硬化门静脉高压症便秘患者作为研究对象,并遵照随机数字表法分成研究组、对照组各56例,研究组给予大黄苏打片+西医综合治疗;对照组给予大黄苏打片,其中30例以3片/d剂量为对照A组,另26例以9片/d剂量为对照B组。治疗后2周对所有患者进行疗效评价,治疗前后分别进行Bristol粪便分型判断,同时在治疗前及治疗后3 d、1周、2周进行血氨水平测定,记录不良反应(恶心、呕吐、腹泻等)发生率及复发率,对比研究组与对照组治疗结果。[结果]研究组中Child A、B、C分级患者的治疗有效率均高出对照组(P<0.05)。治疗前2组的Bristol粪便分型比较差异无统计学意义(P>0.05),治疗后研究组Bristol粪便3~5型患者明显高于对照组(P<0.05)。治疗前研究组与对照组的血氨水平比较差异无统计学意义(P>0.05),治疗后3 d、1周及2周时研究组血氧指标水平低于对照组(P<0.05)。研究组不良反应发生率与对照组比较差异无统计学意义(P>0.05),但研究组复发率低于对照组(P<0.05)。[结论]大黄苏打片+常规西药运用于肝硬化门静脉高压症便秘中效果显著,能够快速改善患者粪便性状,促进血氨水平恢复,降低复发率,安全性高,为预后提供保障。[Objective]To study the clinical value of rhubarb compound tablets plus western medicine in cirrhotic portal hypertension patients with constipation.[Methods]One hundred and twelve cirrhotic portal hypertension patients with constipation treated from June 2017 to February 2019 in our hospital were selected as research subjects.According to random number table, patients were assigned to two groups, 56 cases in each group.The study group was treated with rhubarb compound tablets and western medicine;the control group was treated with rhubarb compound tablets, including 30 cases with 3 tablets/d(group A)and 26 cases with 9 tablets/d(group B).Treatment efficacy was assessed after two weeks.Bristol stool classifications before and 3 days, one week, two weeks after the treatment were confirmed.Blood ammonia contents were measured;incidences of adverse reactions like nausea, emesis and diarrhea and recurrence rate were compared.[Results]The total effective rate in Child A,B and C patients was significantly higher than that in the control group(P<0.05).Before the treatment, Bristol stool classifications between the groups were not significantly different(P>0.05).After the treatment, the ratio of Grade 3-5 patients in the study group was significantly higher than that in group A and group B(P<0.05).Before the treatment, blood ammonia contents between the groups were not significantly different(P>0.05).Three days, one week and two weeks after the treatment, the related indicators in the study group were lower than those group A and group B(P<0.05);the adverse event rate between study group(3.57%)and group A(6.67%),group B(11.54%)was not significantly different(P>0.05);the recurrence rate in the study group(3.57%)was lower than that in group A(13.33%)and group B(23.08%)(P<0.05).[Conclusion]Rhubarb compound tablets combined with western medicine is proven to be effective, which can quickly promote the recovery of blood ammonia contents, improve patient’s stool form, treatment safety and prognosis.

关 键 词：便秘 大黄苏打片 肝硬化门静脉高压症 乳果糖 

分 类 号：R442.2[医药卫生—诊断学]