新生婴儿与老年人红细胞物理特性对比实验  

Comparative Experiment on Physical Properties of Red Blood Cells in Newborn Infants and Elderly People

作　　者：陆启迪 熊瑛[3] 孙奕扬 刘洁 刘心悦[1] 魏桥栋 徐士鑫 龚晓波[1,2] LU Qidi;XIONG Yin;SUN Yiyang;LIU Jie;LIU Xinyue;WEI Qiaodong;XU Shixin;GONG Xiaobo(Department of Engineering Mechanics,Shanghai Jiao Tong University,Shanghai 200240,China;State Key Laboratory of Ocean Engineering,School of Naval Architecture,Ocean and Civil Engineering,Shanghai Jiao Tong University,Shanghai 200240,China,Shanghai 200240,China;Department of General Surgery,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China;Department of Data Science,Kunshan Duke University,Suzhou 215316,Jiangsu,China;Department of Mathematics,Kunshan Duke University,Suzhou 215316,Jiangsu,China)

机构地区：[1]上海交通大学工程力学系,上海200240 [2]上海交通大学海洋工程国家重点实验室,上海200240 [3]上海交通大学医学院附属新华医院普外科,上海200092 [4]昆山杜克大学数据科学系,江苏苏州215316 [5]昆山杜克大学数学系,江苏苏州215316

出　　处：《医用生物力学》2021年第4期638-645,共8页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(11872040);国家重点研发计划政府间国际科技创新合作重点专项(2017YFE0117100)。

摘　　要：目的通过比较新生婴儿与80岁以上老年人红细胞物理特性(细胞表面积、体积和剪切弹性模量)及与总胆固醇、糖化血红蛋白等生理生化参数的相关关系,分析不同年龄和生化参数对红细胞物理特性的影响。方法采用微量吸管技术测量新生婴儿和80岁以上老年人的红细胞表面积、体积和剪切弹性模量,对数据进行统计分布分析、相关性分析和回归分析。结果80岁以上老年人红细胞体积、表面积、剪切弹性模量均值都比新生婴儿红细胞相应参数要小,同年龄组内单个人样本间的红细胞力学参数均值相差不大。新生儿红细胞几何参数分布与老人相比更为集中,而剪切弹性模量分布比老年人红细胞的更分散。新生婴儿红细胞物理特性与总胆固醇和出生孕周相关性高;老年人红细胞物理特性与舒张压和糖化血红蛋白的相关性高。结论新生婴儿与80岁以上老年人的红细胞物理特性有明显差异,影响不同年龄红细胞物理特性的生化指标也不同。Objective By comparing the physical properties(cell area,volume and elastic modulus)of red blood cells(RBCs)between newborn infants and the elderly over 80 years old,and correlation with the physiological and biochemical parameters such as total cholesterol and glycosylated hemoglobin,the effects of different ages and biochemical parameters on RBC physical properties were analyzed.Methods The mcropipette aspiration was used to measure the surface area,volume and elastic modulus of erythrocytes in newborn infants and the elderly over 80 years old,and the data were analyzed by statistical distribution analysis,correlation analysis and regression analysis.Results The mean values of RBC volume,surface area and elastic modulus in the elderly over 80 years old were smaller than those in newborn infants,and the mean values of RBC mechanical parameters in the same age group were not significantly different.The erythrocytes geometric parameter distribution of newborn infants was more concentrated than that of the elderly,while the elastic modulus distribution of newborn infants was more dispersed than that of the elderly.The mechanical properties of RBCs in newborn infants were highly correlated with the total cholesterol and gestational week;the mechanical properties of RBCs in the elderly were highly correlated with diastolic blood pressure and glycated hemoglobin.Conclusions There are significant differences in physical properties of RBCs between newborn infants and the elderly over 80 years old,and the biochemical parameters that affect physical properties of RBCs at different ages are also different.

关 键 词：红细胞 微吸管 总胆固醇 糖化血红蛋白 

分 类 号：R318.01[医药卫生—生物医学工程]